32563-25-0Relevant articles and documents
Practical synthesis of L-erythro- and L-threo-4-fluoroglutamic acids using aminoacylase
Kokuryo, Yoshitsugu,Nakatani, Takuji,Kobayashi, Kobee,Tamura, Yoshinori,Kawada, Kenji,Ohtani, Mitsuaki
, p. 3545 - 3551 (1996)
Enantiomerically pure L-erythro- and L-threo-4-fluoroglutamic acids 1a and 1b were conveniently prepared. The key steps in this synthesis relied upon separation of diastereomers of N-chloroacetyl-4-fluoroglutamic acid 5-methyl ester 7 by recrystallization and enzymatic resolution of enantiomers of the resulting 7(a+c) and 7(b+d) by aminoacylase. Protection of the γ-carboxyl group as a methyl ester was found to be crucial for this enzymatic reaction.
[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION
-
Paragraph 0890, (2016/12/01)
The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
New stereospecific syntheses and x-ray diffraction structures of (-)-D-erythro- And (+)-L-threo-4-fluoroglutamic acid
Hudlicky, Milos,Merola, Joseph S.
, p. 7403 - 7406 (2007/10/02)
Stereospecific syntheses of (+)-L-threo and (-)-D-erythro-4-fluoroglutamic acid are based on the hydrolysis of methyl 1-acetyl-4-fluoro-L-pyrrolidin-5-one-2-carboxylate, prepared from trans- and cis-4-hydroxyprolines, respectively.
