32570-23-3

Basic information

• Product Name: 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE
• Synonyms: 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE;2,5-DIMETHYL-1-(3-NITROPHENYL)PYRROLE
• CAS NO: 32570-23-3
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 32570-23-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 352.3 °C at 760 mmHg
• Flash Point: 166.9 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 7.87E-05mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE(32570-23-3)
• EPA Substance Registry System: 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE(32570-23-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 32570-23-3(Hazardous Substances Data)

Usage

General Description

1-(3-Nitrophenyl)-2,5-dimethylpyrrole is a chemical compound with a molecular formula C13H12N2O2. It is a pyrrole derivative that contains a nitro group and two methyl groups. 1-(3-NITROPHENYL)-2,5-DIMETHYLPYRROLE is often used in organic synthesis and in the production of dyes and pigments. It has also been studied for potential pharmaceutical applications, particularly in the development of new drugs with antimicrobial, anti-inflammatory, or anticancer properties. Its unique structure and chemical properties make it a valuable building block for the creation of various organic compounds.

InChI:InChI=1/C12H12N2O2/c1-9-6-7-10(2)13(9)11-4-3-5-12(8-11)14(15)16/h3-8H,1-2H3

Upstream product

• 110-13-4 2,5-hexanedione 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 423753-42-8 2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrole-3-carbaldehyde 
• 247225-33-8 3-(2,5-dimethyl-1H-pyrrol-1-yl)aniline 

Relevant articles and documents

Crystalline salicylic acid as an efficient catalyst for ultrafast Paal–Knorr pyrrole synthesis under microwave induction

Abstract: In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids as organocatalysts has been investigated for solvent-free Paal–Knorr pyrrole synthesis under microwave activation. Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst because its efficiency remained high even under low microwave power irradiation or a shorter reaction time for the model reaction. The outstanding catalytic activity of salicylic acid allowed the Paal–Knorr cyclocondensation with a turnover frequency up to 1472?h?1 which is unique in the context of a metal-free homogeneous catalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with no risk of metal contamination. Graphic abstract: [Figure not available: see fulltext.] Synopsis: A green and expeditious protocol for the synthesis of 2,5-dimethylpyrroles via combination of salicylic acid as catalyst (in its solid state) and microwaves has been introduced.

Synthesis, structure and in vitro anti-trypanosomal activity of non-toxic arylpyrrole-based chalcone derivatives

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured Trypanosoma brucei brucei 427 strain. Several compounds displayed mostly modest in vitro anti-trypanosomal activity with compounds 10e and 10h emerging as active candidates with IC50 values of 4.09 and 5.11 μM, respectively. More importantly, a concomitant assessment of their activity against a human cervix adenocarcinoma (HeLa) cell line revealed that these compounds are non-toxic.

Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor

The N-Methyl-d-Aspartate receptor (NMDAR) is involved in many neurological and psychiatric disorders including Alzheimer's disease and schizophrenia. The aim of this study was to develop a positron emission tomography (PET) ligand to assess the bio-availa