325721-70-8Relevant articles and documents
Phosphotungstic acid: An efficient catalyst for the aqueous phase synthesis of bis-(4-hydroxycoumarin-3-yl)methanes
Singh, Prashant,Kumar, Pradeep,Katyal, Anju,Kalra, Rashmi,Dass, Sujata K.,Prakash, Satya,Chandra, Ramesh
, p. 303 - 308 (2010)
In this present work, we report that phosphotungstic acid provides a simple, efficient and environmentally benign route is a two-component one-pot domino Knoevenagel-type condensation/Michael reaction between 4-coumarin derivative and an aldehyde in water
Facile and Straightforward Synthesis of Racemic Version of Substituted 3-[3-(2-Hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins: Easy Access to a Series of Biorelevant Warfarin Analogues
Brahmachari, Goutam,Mandal, Mullicka,Karmakar, Indrajit
, p. 451 - 464 (2021/10/19)
The present communication deals with a straightforward, efficient, and green synthesis of a series of racemic version of 3-[3-(2- hydroxyphenyl)-3-oxo-1-arylpropyl]-4-hydroxycoumarins as biologically interesting warfarin analogues upon decarboxylative hyd
Unveiling the anti-tubercular properties of biscoumarins, through biological evaluation and docking studies
Acharya, Poornima,Ramana,Upadhyay, Manish,Pavale, Ganesh
, p. 57 - 66 (2021/02/27)
Background: Biscoumarin scaffolds are known for their promising pharmacological properties. These compounds have not been studied for their activity against tuberculosis strains. Objective: Unveil the antitubercular properties of biscoumarin scaffolds. Me
CAL-B accelerated novel synthetic protocols for 3,3’-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates
Chavan, Anusaya S.,Kharat, Arun S.,Bhosle, Manisha R.,Dhumal, Sambhaji T.,Mane, Ramrao A.
, p. 4497 - 4512 (2021/07/26)
Green protocols for the syntheses of 3,3′-arylidenebis-4-hydroxycoumarins and dimethyl ((substituted phenyl) (phenylamino)methyl) phosphonates have been first time developed using biocatalyst, CAL-B (lipase). These are carried at room temperature under st
Black yet green: A?heterogenous carbon-based acid catalyst for the synthesis of biscyclic derivatives under eco-friendly conditions
Agarwal, Shikha,Sethiya, Ayushi,Teli, Pankaj
, (2021/12/09)
In this study, a simple, cost-efficient and green protocol has been described for the synthesis of biscoumarin and bisdimedone derivatives via one-pot Knoevenagel–Michael reaction of aromatic aldehydes with 4-hydroxycoumarin and dimedone, respectively. Th
A class of 4 - hydroxy dicoumarol compound and use thereof
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Paragraph 0040; 0041; 0042; 0043; 0074; 0075, (2018/11/03)
The invention relates to a 4-hydroxyl bishydroxycoumarin compound and its application. The structural formula of the compound is as shown in the formula I. The application is an application of the compound used as a bactericide of staphylococcus aureus or staphylococcus epidermidis. In the formula I, R is 3,4-2F, 3,5-2F, 3-I, 4-I, 3-CF3, 4-CF3 or 3,5-2CF3.
Choline Hydroxide: An Efficient and Biocompatible Basic Catalyst for the Synthesis of Biscoumarins Under Mild Conditions
Zhu, Anlian,Bai, Shukun,Li, Lingjun,Wang, Mingyue,Wang, Jianji
, p. 1089 - 1093 (2015/02/05)
In this work, choline hydroxide is found to be an efficient and green catalyst for the synthesis of biscoumarins through the Domino Knoevenagel-Michael reaction of a series of aldehydes with 4-hydroxylcoumarin under mild conditions. A series of aldehydes with different substituted functional groups, especially those which are sensitive to acid, have been converted to biscoumarins with good to excellent isolated yields, and the reactions can be easily scaled up to multigrams. The target products can be simply separated by filtration, and the aqueous solution of choline hydroxide (as filtrate) can then be reused for the next run reaction.
Tetramethylguanidium-based ionic liquids as efficient and reusable catalysts for the synthesis of biscoumarin at room temperature
Zhu, Anlian,Wang, Mingyue,Li, Lingjun,Wang, Jianji
, p. 73974 - 73979 (2015/09/15)
In this work, a basic ionic liquid, tetramethylguanidium acetate ([TMG][Ac]), was found to be an efficient catalyst for the one-pot preparation of biscoumarins through a domino Knoevenagel-Michael reaction at room temperature. This novel catalytic system
Benzylidene-bis-(4-hydroxycoumarin) and benzopyrano-coumarin derivatives: Synthesis, 1H/13C-NMR conformational and X-ray crystal structure studies and in vitro antiviral activity evaluations
Zavrsnik, Davorka,Muratovic, Samija,Makuc, Damjan,Plavec, Janez,Cetina, Mario,Nagl, Ante,De Clercq, Erik,Balzarini, Jan,Mintas, Mladen
experimental part, p. 6023 - 6040 (2011/09/20)
We report on the synthesis of 4-hydroxycoumarin dimers 1-15 bearing an aryl substituent on the central linker and fused benzopyranocoumarin derivatives 16-20 and on their in vitro broad anti-DNA and RNA virus activity evaluations. The chemical identities
COUMARIN-BASED COMPOUNDS
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Page/Page column 137, (2010/07/09)
Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compoun
