325820-32-4

Upstream product

• 6850-57-3 2-methoxybenzylamine 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 349091-25-4 N-(2-methoxy-benzyl)-4-nitro-benzamide 

Downstream Products

• 325820-36-8 C₃₀H₃₀N₄O₅S 
• 325820-38-0 2-[N-(2'-Methoxybenzylcarbamoyl)amino]-5-(N'-methyl-N'-fluorenylmethylcarbonylamino)-1,4,5,6-tetrahydropyrimidin-4-one 
• 325820-35-7 C₂₀H₂₈N₄O₅S 
• 325820-39-1 2-[N-(2'-Methoxybenzylcarbamoyl)amino]-5-N'-methyl-1,5,6-trihydropyrimidin-4-one 
• 325820-33-5 C₂₀H₃₀N₄O₆S 
• 325820-34-6 C₃₀H₃₂N₄O₆S 

Relevant academic research and scientific papers

Assembly of the TAN-1057 A/B heterocycle from a dehydroalanine precursor

A tandem reaction process was used to form the tetrahydropyrimidinone core of the TAN-1057 A and B dipeptide antibiotics. Michael addition of ammonia to a dehydroalanine derivative, followed by intramolecular displacement of an S-methylisothiourea assembles the tetrahydropyrimidinone in one-step.