32632-24-9

Upstream product

• 6784-45-8 1-chloro-3,7,11-trimethyldodeca-2,6,10-triene 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 24163-94-8 (2E,6Z)-1-bromo-3,7,11-trimethyl-2,6,10-dodecatriene 

Downstream Products

• 183583-82-6 N-(1,2-diethyl-4-pyrazolidinyl)-4-(trans, trans-farnesyloxy) benzamide 
• 34596-41-3 p-[(3,7,11-trimethyl-dodeca-2,6,10-trienyl)oxy]benzoic acid propargyl ester 

Relevant academic research and scientific papers

2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

The high mortality rate and the increasing prevalence of Mtb resistance are the major concerns for the Tuberculosis (TB) treatment in this century. To counteract the prevalence of Mtb resistance, we have synthesized 2-aryl benzazole based dual targeted molecules. Compound 9m and 9n were found to be equally active against replicating and non-replicating form of Mtb (MIC(MABA) 1.98 and 1.66 μg/ml; MIC(LORA) 2.06 and 1.59 μg/ml respectively). They arrested the cell division (replicating Mtb) by inhibiting the GTPase activity of FtsZ with IC50 values 45 and 64 μM respectively. They were also capable of kill Mtb in non-replicating form by inhibiting the biosynthesis of menaquinone which was substantiated by the MenG inhibition (IC50 = 11.62 and 7.49 μM respectively) followed by the Vit-K2 rescue study and ATP production assay.

Pyrrolidine derivative, anti-ulcer drug, and antibacterial drug

A pyrrolidine derivative or a salt thereof expressed by the following formula 1: STR1 wherein R1 is an alkenyl group; R2 is a lower alkoxy group or a halogen atom; R3 is a lower alkyl group; X is a group expressed by --O-- or --S--; Y is carbon or nitrogen atom; m is an integer of 1 to 3; and n is an integer of 0 to 2. The pyrrolidine derivative has an anti-ulcer effect or an antibacterial activity against Helicobacter pyroli, and has also high safety to be available for prevention or cure of ulcers.

Alkylenediamine derivative, anti-ulcer drug, and antibacterial drug

An alkylenediamine derivative or a salt thereof expressed by the following formula 1: STR1 wherein each of R1 and R2 represents a lower alkyl group, and W represents a group expressed by any of the following formulas 2 and 3; STR2 wh

Alkylenediamine derivative anti-ulcer drug and antibacterial drug

The invention provides a compound which has anti-ulcer effect and antibacterial activity against Helicobacter pyroli. This compound is an alkylenediamine derivative or salt which has a general formula of (1): STR1 wherein each of R4, R5/s

Pyrazolidine derivative radical scavenger brain-infarction depressant and brain-edema depressant

A pyrazolidine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: STR1 wherein A represents a group expressed by --CH2 --, --CO--, --CS--, --CH2 CO--, or --CH=CH--CO--; B represents a group expressed by --O-- or --NH--; n is an integer of 1 or 2; R represents an alkenyl group; and R1 and R2 represent a lower alkyl or benzyl group. The pyrazolidine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

Sebosuppressive topical preparations

Alkyl and alkenyl aryl ether derivatives corresponding to the formula: STR1 in which R1 is a saturated cycloaliphatic C6 -C20 alkyl group or a mono- or polyunsaturated, linear, branched or cycloaliphatic C6 -Cs

Alkynyloxy-phenyl derivatives

Alkynyl, benzyl or phenyl, ethers and esters which are ring substituted with an oxy or a thio aliphatic chain. These ethers and esters are useful in killing and preventing the proliferation of insects by upsetting their hormonal balance.