32645-65-1

Basic information

• Product Name: thymidine glycol
• Synonyms: thymidine glycol;5,6-Dihydro-5,6-dihydroxy-3-(2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• CAS NO: 32645-65-1
• Molecular Formula: C₁₀H₁₆N₂O₇
• Molecular Weight: 276.24
• Mol File: 32645-65-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.645g/cm³
• Refractive Index: 1.624
• PKA: 10.48±0.40(Predicted)
• CAS DataBase Reference: thymidine glycol(CAS DataBase Reference)
• NIST Chemistry Reference: thymidine glycol(32645-65-1)
• EPA Substance Registry System: thymidine glycol(32645-65-1)

Safety Data

• Hazardous Substances Data: 32645-65-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H16N2O7/c1-10(18)7(15)11-9(17)12(8(10)16)6-2-4(14)5(3-13)19-6/h4-6,8,13-14,16,18H,2-3H2,1H3,(H,11,15,17)/t4-,5+,6+,8?,10?/m0/s1

Upstream product

• 50-89-5 thymidine 
• 43179-29-9 (5R,6R)-trans-(+)-5-bromo-6-hydroxy-5,6-dihydrothymidine 

Downstream Products

• 50-89-5 thymidine 

Relevant articles and documents

Sonochemical transformation of thymidine: A mass spectrometric study

Abstract Ultrasound is extensively used in medical field for a number of applications including targeted killing of cancer cells. DNA is one of the most susceptible entities in any kind of free radical induced reactions in living systems. In the present work, the transformation of thymidine (dT) induced by ultrasound (US) was investigated using high resolution mass spectrometry (LC-Q-ToF-MS). dT was subjected to sonolysis under four different frequencies (200, 350, 620 and 1000 kHz) and at three power densities (10.5, 24.5 and 42 W/mL) in aerated as well as argon saturated conditions. A total of twenty modified nucleosides including non-fully characterized dT dimeric compounds were detected by LC-Q-ToF-MS. Out of these products, seven were obtained only in the argon atmosphere and two only in the aerated conditions. Among the identified products, there were base modified products and sugar modified products. The products were formed by the reaction of hydroxyl radical and hydrogen atom. Under aerated conditions, the reactions proceed via the formation of hydroperoxides, while in argon atmosphere disproportionation and radical recombinations predominate. The study provides a complete picture of sonochemical transformation pathways of dT which has relevance in DNA damage under ultrasound exposure.

Oxidation of Thymidine by Peroxymono- and Peroxodisulfate Ions

Oxidation of thymidine by KHSO5 gave thymidine glycols, while a similar treatment with Na2S2O8 gave 5-hydroxymethyl-2'-deoxyuridine.