326474-55-9Relevant academic research and scientific papers
Alkyne cross metathesis reactions of extended scope
Fuerstner, Alois,Mathes, Christian
, p. 221 - 223 (2001)
equation presented A catalyst formed in situ from Mo[N(t-Bu)(Ar)]3 1 (Ar = 3,5-dimethylphenyl) and CH2Cl2 in toluene effects cross metathesis reactions of functionalized alkynes that are beyond reach of more traditional promotors. An application to the synthesis of prostaglandin E2 (PGE2) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates.
Synthesis of thioacetate-functionalized cobalt(II) porphyrins and their immobilization on gold surface - Characterization by X-ray photoelectron spectroscopy
Ell, Alida H.,Csjernyik, Gabor,Slagt, Vincent F.,Baeckvall, Jan-E.,Berner, Simon,Puglia, Carla,Ledung, Greger,Oscarsson, Sven
, p. 1193 - 1199 (2007/10/03)
Cobalt tetraarylporphyrins 1-Co and 2-Co with thioacetate-functionalized carbon chains on the aryl groups were synthesized. The cobalt porphyrin 2-Co was immobilized on a gold surface after deprotection of the S-acetyl group. The immobilized porphyrin was
Alkyne metathesis: Development of a novel molybdenum-based catalyst system and its application to the total synthesis of epothilone A and C
Fuerstner, Alois,Mathes, Christian,Lehmann, Christian W.
, p. 5299 - 5317 (2007/10/03)
Sterically hindered molybdenum(III) amido complexes of the general type [Mo{(tBu)(Ar)N}3] (1), upon treatment with CH2Cl2 or other halogen donors, have been converted into highly effective catalysts for all kinds of alkyne metathesis reactions. Although the actual nature of the propagating species formed in situ is still elusive, halogen transfer to the Mo center of 1 plays a decisive role in the activation of such precatalysts. It was possible to isolate and characterize by X-ray crystallography some of the resulting molybdenum halide derivatives such as 15, 16 and 20 which themselves were shown to be catalytically active. Numerous applications illustrate the performance of the catalytic system 1/CH2Cl2 which operates under mild conditions and tolerates an array of polar functional groups. The wide scope allows the method to be implemented into the total synthesis of sensitive and polyfunctional natural products. Most notable among them is a concise entry into the potent anticancer agents epothilone A (86) and C (88). The macrolide core of these targets is forged by ring closing alkyne metathesis (RCAM) of diyne 113, followed by Lindlar hydrogenation of cycloalkyne 114 thus formed. Since this strategy opens a stereoselective entry into (Z)-alkene 115, the approach is inherently more efficient than previous syntheses based on conventional RCM. Wiley-VCH Verlag GmbH, 2001.
