326488-07-7

Upstream product

• 141-97-9 ethyl acetoacetate 
• 140-69-2 4-methoxybenzylhydrazine 
• 1193354-87-8 C₁₉H₁₆F₂N₂O₃ 
• 1193354-83-4 C₁₉H₁₈N₂O₃ 

Downstream Products

• 1193354-88-9 C₂₀H₁₈F₂N₂O₃ 
• 1193354-83-4 C₁₉H₁₈N₂O₃ 
• 1193354-87-8 C₁₉H₁₆F₂N₂O₃ 
• 412327-09-4 [5-hydroxy-1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl]-phenyl-methanone 

Relevant academic research and scientific papers

Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

West Nile Virus (WNV) is a potentially deadly mosquito-borne flavivirus which has spread rapidly throughout the world. Currently there is no effective vaccine against flaviviral infections. We previously reported the identification of pyrazole ester derivatives as allosteric inhibitors of WNV NS2B-NS3 proteinase. These compounds degrade rapidly in pH 8 buffer with a half life of 1-2 h. We now report the design, synthesis and in vitro evaluation of pyrazole derivatives that are inhibitors of WNV NS2B-NS3 proteinase with greatly improved stability in the assay medium.

Anti-HIV pyrazole derivatives

The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors