326499-02-9

Upstream product

• 326498-96-8 (S)-4-benzyl-2-(2-trimethylsilylethynyl)-1,3-oxazoline 
• 326498-85-5 N-[(S)-1-benzyl-2-hydroxyethyl]-3-trimethylsilylprop-2-ynamide 
• 839698-01-0 (1S)-3-(triisopropylsilanyl)propynoic acid (1-benzyl-2-hydroxyethyl)amide 
• 839698-02-1 (4S)-4-benzyl-2-[(triisopropylsilanyl)ethynyl]-4,5-dihydrooxazole 

Relevant academic research and scientific papers

Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines

A method for the synthesis of 2-alkynyl oxazoles and oxazolines was discussed. These compounds were synthesized from readily available starting materials and were sufficiently polarized to participate in nucleophillic conjugate addition reactions. The addition of an acetate salt to the reaction mixture was found to be improving the overall yield. The conjugate addition reaction of heteronucleophiles to oxazole and oxazoline alkynes offers a versatile approach to produce heterocyclic building blocks for the synthesis of biologically active products.

A convenient synthesis of chiral 2-alkynyl-1,3-oxazolines

A general, high-yielding, two-step synthesis of chiral 2-alkynyl-1,3-oxazolines starting from 2-alkynoic acids and 2-aminoalcohols is disclosed. (C) 2000 Published by Elsevier Science Ltd.