3265-23-4

Basic information

• Product Name: 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE
• Synonyms: 1H-Indole-2,3-dione,1-Methyl-, 3-hydrazone
• CAS NO: 3265-23-4
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 3265-23-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 342.9°Cat760mmHg
• Flash Point: 161.2°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 7.29E-05mmHg at 25°C
• Refractive Index: 1.675
• PKA: -2.17±0.20(Predicted)
• CAS DataBase Reference: 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE(3265-23-4)
• EPA Substance Registry System: 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE(3265-23-4)

Safety Data

• Hazardous Substances Data: 3265-23-4(Hazardous Substances Data)

Usage

General Description

3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE is a chemical compound with the molecular formula C9H10N2O. It is a heterocyclic compound with an indole backbone and a hydrazono functional group. 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE has potential applications in pharmaceutical and medicinal chemistry due to its diverse biological activities, including anti-inflammatory and anti-cancer properties. Its unique structure and reactivity make it a valuable tool for drug discovery and development. Further research on the properties and potential applications of 3-HYDRAZONO-1-METHYL-1,3-DIHYDRO-INDOL-2-ONE is ongoing, and it holds promise for future therapeutic interventions.

InChI:InChI=1/C9H9N3O/c1-12-7-5-3-2-4-6(7)8(11-10)9(12)13/h2-5H,10H2,1H3/b11-8+

Upstream product

• 91-56-5 indole-2,3-dione 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 3265-14-3 3-diazo-1-methyl-1,3-dihydro-indol-2-one 

Downstream Products

• 1139780-27-0 C₁₇H₁₄N₄O₂S 

Relevant articles and documents

Electrochemical synthesis of a 6-coordinate cadmium(II) complex with N-methylisatin N(4)-cyclohexylthiosemicarbazone

Cadmium metal was oxidized in the presence of N-methylisatin N(4)-cyclohexyl-thiosemicarbazone (HMeIs4Chex) in an acetonitrile solution, which produced a complex of the formula [Cd(MeIs4Chex)2]. The two MeIs4Chex ligands are at an angle close to 90° from each other, and there is hydrogen bonding to two adjacent molecules by the anionic ligands remaining NH groups. The complex crystallizes in the monoclinic space group P21/c with a = 11.820(4), b = 11.491(4), c = 27.834(4) A, β = 106.82(2)°, V = 3618.7(17) A°3 and Z = 4.

Squaramide-catalyzed asymmetric Mannich reactions between 3-fluorooxindoles and pyrazolinone ketimines

An enantioselective Mannich reaction between 3-fluorooxindoles and pyrazolinone ketimines has been developed for the construction of amino-pyrazolone-oxindoles containing stereogenic C-F units. Based on this new protocol that allows for the generation of two adjacent tetrasubstituted stereocenters, a variety of structurally diverse fluorinated amino-pyrazolone-oxindoles were obtained in good to excellent yields with excellent diastereoselectivities and enantioselectivities (up to 98% yield, >20:1 dr and >99% ee). What's more, good yield and high stereoselectivities were obtained in the gram-scale reaction.

Solvent Effects: Syntheses of 3,3-Difluorooxindoles and 3-Fluorooxindoles from Hydrazonoindolin-2-one by Selectfluor

Efficient syntheses of 3,3-difluorooxindoles and 3-fluorooxindoles via fluorination of hydrazonoindolin-2-one with Selectfluor are reported. Under different solvent conditions, this method produced 3,3-difluorooxindoles and 3-fluorooxindoles selectively. The broad substrate scope and mild reaction conditions make this transformation a valuable method in drug discovery and development.