32651-37-9Relevant academic research and scientific papers
Palladium(II)-catalysed Oxidative Ring Cleavage of Cyclic Acetals with t-Butyl Hydroperoxide: Preparation of Monoesters of Diols
Hosokawa, Takahiro,Imada, Yasushi,Murahashi, Shun-Ichi
, p. 1245 - 1246 (1983)
Reaction of five- and six-membered cyclic acetals with tBuOOH in the presence of palladium(II) catalyst gives monoesters of diols in good yields.
Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols
Burde, Ameya S.,Karyakarte, Shuklendu D.,Sylvester, Eric D.,Chemler, Sherry R.
supporting information, p. 105 - 108 (2021/01/14)
Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes
Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents
Ye, Chanyuan,Xu, Rui,Cao, Zhongcheng,Song, Qing,Yu, Guangjun,Shi, Yichun,Liu, Zhuoling,Liu, Xiuxiu,Deng, Yong
, (2021/04/22)
A series of 4-aminoalkyl-1(2H)-phthalazinone derivatives was designed and synthesized as potential multifunctional agents for Alzheimer's disease (AD) treatment. In vitro biological assay results demonstrated that most synthesized compounds exhibited sign
Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using Iodine Tris(trifluoroacetate)
Matsuoka, Keitaro,Komami, Narumi,Kojima, Masahiro,Mita, Tsuyoshi,Suzuki, Kimichi,Maeda, Satoshi,Yoshino, Tatsuhiko,Matsunaga, Shigeki
, p. 103 - 108 (2021/01/13)
Organosilanes are synthetically useful reagents and precursors in organic chemistry. However, the typical inertness of unactivated Si-C(sp3) bonds under conventional reaction conditions has hampered the application of simple tetraalkylsilanes in organic synthesis. Herein we report the chemoselective cleavage of Si-C(sp3) bonds of unactivated tetraalkylsilanes using iodine tris(trifluoroacetate). The reaction proceeds smoothly under mild conditions (-50 °C to room temperature) and tolerates various polar functional groups, thus enabling subsequent Tamao-Fleming oxidation to provide the corresponding alcohols. NMR experiments and density functional theory calculations on the reaction indicate that the transfer of alkyl groups from Si to the I(III) center and the formation of the Si-O bond proceed concertedly to afford an alkyl-λ3-iodane and silyl trifluoroacetate. The developed method enables the use of unactivated tetraalkylsilanes as highly stable synthetic precursors.
Synthesis and mesomorphic properties of H-bonded side-chain liquid crystal polymers of two modifications of poly(4-vinylphenol) and poly(4-vinylpyridine)
Muhammad, Khushi,Siddiqi, Humaira M.,Hameed, Shahid
, p. 14 - 25 (2021/02/02)
Poly(4-vinylphenol) was modified to poly(4-(4-vinylphenoxy)butan-1-ol) and poly(4-(6-(4-vinylphenoxy)hexyloxy)benzoic acid). Methyl 4-((E)-2-pyridin-4-yl)vinyl)benzoate ligand was synthesized and hydrogen bonded with two modified polymers. Complexes of po
Electrochemical esterification reaction of alkynes with diols: Via cleavage of carbon-carbon triple bonds without catalyst and oxidant
Cheng, Hui-Hui,Gao, Hui,Li, Pin-Hua,Shen, Hui-Zhi,Wang, Pei-Long
supporting information, p. 6783 - 6791 (2020/11/09)
A novel electrochemical esterification of alkynes for the synthesis of esters was developed in which diols and their derivatives were used as the partners. This method is green as it is catalyst-free, oxidant-free, and additive-free and shows atom-economy. This is the first example of an electrochemical reaction via cleavage of carbon-carbon triple bonds. Meanwhile, this is also the first example of a carbon-carbon triple bond cleavage reaction of alkynes with diols. This journal is
Protecting-group-free synthesis of hydroxyesters from amino alcohols
Joseph-Valcin, Eve-Marline,Lebel, Hélène,Reynard, Guillaume
supporting information, p. 10938 - 10941 (2020/10/02)
The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of functional groups.
Axial-to-Central Chirality Transfer for Construction of Quaternary Stereocenters via Dearomatization of BINOLs
Min, Xiao-Long,Xu, Xu-Ran,He, Ying
supporting information, p. 9188 - 9193 (2019/11/14)
All-carbon quaternary stereocenters are versatile building blocks, and their asymmetric construction has attracted much attention. Herein, we disclose an axial-to-central chirality transfer strategy for the synthesis of chiral quaternary stereocenters via dearomatization of (S)-BINOLs. The reaction proceeded smoothly with a wide range of propargyl carbonates to afford chiral spiro-compounds in high yields with excellent enantioselectivities. In addition, the strategy was extended to kinetic resolution of rac-BINOLs albeit with moderate s value.
ANTIBACTERIAL COMPOSITION INCLUDING BENZOIC ACID ESTER AND METHODS OF INHIBITING BACTERIAL GROWTH UTILIZING THE SAME
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Page/Page column 23-24, (2018/08/26)
Antibacterial compositions and methods for inhibiting bacterial growth are disclosed. The antibacterial compositions can include a carrier and an antibacterial agent including a benzoic acid ester. The benzoic acid ester can have a carbon chain having a length of two to ten. The benzoic acid ester can have a hydroxyl group on the carbon chain.
Catalytic Oxygenative Allylic Transposition of Alkenes into Enones with an Azaadamantane-Type Oxoammonium Salt Catalyst
Nagasawa, Shota,Sasano, Yusuke,Iwabuchi, Yoshiharu
supporting information, p. 10276 - 10279 (2017/08/07)
The first catalytic oxygenative allylic transposition of unactivated alkenes into enones has been developed using an oxoammonium salt as the catalyst. This reaction converts various tri- and trans-disubstituted alkenes into their corresponding enones with transposition of their double bonds at ambient temperature in good yields. The use of a less-hindered azaadamantane-type oxoammonium salt as the catalyst and a combination of two distinct stoichiometric oxidants, namely, iodobenzene diacetate and magnesium monoperoxyphthalate hexahydrate (MMPP?6 H2O) are essential to facilitate the enone formation efficiently.
