326595-66-8

Basic information

• Product Name: 4-BROMO-3-NITROBENZYL BROMIDE
• Synonyms: 4-BROMO-3-NITROBENZYL BROMIDE
• CAS NO: 326595-66-8
• Molecular Formula: C₇H₅Br₂NO₂
• Molecular Weight: 294.93
• Mol File: 326595-66-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 325.8°Cat760mmHg
• Flash Point: 150.8°C
• Appearance: /
• Density: 2.006g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-BROMO-3-NITROBENZYL BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-NITROBENZYL BROMIDE(326595-66-8)
• EPA Substance Registry System: 4-BROMO-3-NITROBENZYL BROMIDE(326595-66-8)

Safety Data

• Hazardous Substances Data: 326595-66-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-3-nitrobenzyl bromide is a chemical compound with the formula C7H5Br2NO2. It is a potent electrophile and is commonly used as a building block in organic synthesis for the preparation of various biologically active compounds and pharmaceuticals. 4-BROMO-3-NITROBENZYL BROMIDE is a brominated nitroaromatic derivative that is highly reactive due to the presence of both a nitro group and a bromine atom. It is often used in the synthesis of diverse compounds, such as benzyl bromides, nitrophenyl ethers, and other derivatives, by reacting with various nucleophiles. Additionally, it is used as a reagent in the preparation of 3-substituted coumarins and other heterocycles. Due to its high reactivity and versatility, 4-bromo-3-nitrobenzyl bromide is an important intermediate in organic chemistry.

InChI:InChI=1/C7H5Br2NO2/c8-4-5-1-2-6(9)7(3-5)10(11)12/h1-3H,4H2

Upstream product

• 163596-75-6 4-bromo-3-nitrobenzaldehyde 
• 5326-34-1 4-Bromo-3-nitrotoluene 
• 145547-97-3 (4-bromo-3-nitrophenyl)methanol 

Downstream Products

• 851799-35-4 (E)-2',4',6'-trimethoxystyryl-4-bromo-3-aminobenzylsulfone 
• 1330633-74-3 (E)-2',4',6'-trimethoxystyryl-4-bromo-3-nitrobenzylsulfone 
• 1330633-54-9 4-bromo-3-nitrobenzylsulfonylacetic acid 
• 1330633-50-5 4-bromo-3-nitrobenzylthioacetic acid 
• 16096-32-5 4-methyl-1H-indole 
• 627487-97-2 N-methyl-2-(4'-acetoxymethyl-2'-nitrophenylthio)benzamide 
• 627487-40-5 2-[[4-[(acetyloxy)methyl]-2-nitrophenyl]thio]benzoic acid 
• 1026457-07-7 N-methyl-2-(4'-acetoxymethyl-2'-aminophenylthio)benzylamine 
• 853180-72-0 [3-amino-4-(2-methylaminomethyl-phenylsulfanyl)-phenyl]-methanol 
• 853180-68-4 2-bromo-5-acetoxymethylnitrobenzene 

Relevant articles and documents

Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors

The PARP-2 selective inhibitor is important for clarifying specific roles of PARP-2 in the pathophysiological process and developing desired drugs with reduced off-target side effects. In this work, a series of novel quinazoline-2,4(1H,3H)-dione derivatives was designed and synthesized to explore isoform selective PARP inhibitors. As a result, compound 11a (PARP-1 IC50?=?467?nM, PARP-2 IC50?=?11.5?nM, selectivity PARP-1/PARP-2?=?40.6) was disclosed as the most selective PARP-2 inhibitor with high potency to date. The binding features of compound 11a within PARP-1 and PARP-2 were investigated respectively to provide useful insights for the further construction of new isoform selective inhibitors of PARP-1 and PARP-2 by using CDOCKER program.

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia

A dihydroquinolinone moiety was found to be a potent serotonin reuptake inhibitor pharmacophore when combined with certain amines. This fragment was coupled with selected D2 ligands to prepare a series of dual acting compounds with attractive in vitro profiles as dopamine D2 partial agonists and serotonin reuptake inhibitors. Structure-activity studies revealed that the linker plays a key role in contributing to D2 affinity, function, and SRI activity.

Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2′-amino-4′-substituted-phenylthio)benzylamines: Potential candidates as selective serotonin transporter radioligands

A series of N,N-dimethylated and N-monomethylated analogues of N,N-dimethyl-2-(2′-amino-4′-iodophenylthio)benzylamine substituted at the 4′-phenyl position have been prepared and evaluated in vitro for serotonin transporter (SERT) selectivity. Several der