326604-37-9

Upstream product

• 499784-00-8 4-methylthiophenacyl 4-methoxyphenylacetate 
• 499784-03-1 3-(4-methoxyphenyl)-4-(4-methylsulfanylphenyl)-2,5-dihydro-2-furanone 
• 42445-46-5 2-bromo-1-(4-methylsulfanyl-phenyl)-ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 1778-09-2 4-(Methylthio)acetophenone 
• 162011-89-4 3-(4-methoxyphenyl)-4-[4-(methylsulfonyl)phenyl]-2,5-dihydrofuran-2-one 

Relevant academic research and scientific papers

Isomeric acetoxy analogues of rofecoxib: A novel class of highly potent and selective cyclooxygenase-2 inhibitors

A group of isomers possessing a 2-, 3-, or 4-acetoxy moiety on the 3-phenyl substituent of rofecoxib were synthesized that exhibit highly potent, and selective, COX-2 inhibitory activity that have the potential to acetylate the COX-2 isozyme.

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx(TM))

Metabolites of the COX-2 inhibitor rofecoxib (MK-0966, Vioxx(TM)) were prepared by synthetic or biosynthetic methods. Metabolites include products of oxidation, glucuronidation, reduction and hydrolytic ring opening. Based on an in vitro whole blood assay