32675-37-9Relevant academic research and scientific papers
Thionation of Tryptanthrin, Rutaecarpine, and Related Molecules with a Reagent Prepared from P4S10 and Pyridine
Kingi, Ngarita,Bergman, Jan
, p. 7711 - 7716 (2016)
Reaction of P4S10 in hot pyridine produces a crystalline solid which can be collected and used for thionations in other solvents such as acetonitrile and sulfolane. The biologically active natural products tryptanthrine, rutaecarpine, 7,8-dehydrorutaecarpine, and some related compounds have now been converted to thionated versions simply by heating the molecules with this thionating reagent in sulfolane (typically at 135 °C for 20 min) followed by a workup in water. No chromatography was necessary.
Pharmaceutical methods of using heterocyclic derivatives of N-phenylamides
-
, (2008/06/13)
New central nervous system agents conform to formula I: STR1 wherein R=H or C 1-4 alkoxy;X=CH or N;Y=NH, O or S;Z=C 1-4 alkyl, C 3-6 cycloalkyl, C 2-3 alkenyl, NH 2, C 1-4 alkylamino, or C 1-4 alkoxyalkyl, with the proviso that Z may not be CH 3 when R=H, X=CH, and Y=NH and Z may not be CH 3 when R=H, X=N and Y=NH and NHC(O)Z is in the para- position.
