32687-35-7

Upstream product

• 197785-44-7 1-(1-azido-2-bromoethyl)-4-chlorobenzene 
• 23135-16-2 1,2-dibromo-1-(4-chlorophenyl)ethane 
• 1354970-09-4 1-(1-azido-2-iodoethyl)-4-chlorobenzene 

Downstream Products

• 89414-87-9 (3R,4S)-4-(4-Chloro-phenyl)-2,5-dioxo-pyrrolidine-3-carboxylic acid ethyl ester 
• 74376-33-3 2,5-bis(4-chlorophenyl)pyrazine 
• 136612-01-6 C₁₇H₁₂Cl₃N₃O₃S 
• 136611-98-8 2,7-Bis-(4-chloro-phenyl)-5-oxo-1,4,6-triaza-tricyclo[5.1.0.0^2,4]octane-6-sulfonyl chloride 
• 1169881-06-4 fac-[Re(I)Br(CO)3(3-p-chorophenyl-2H-azirine)2] 
• 906781-10-0 2-(4-chlorophenyl)-1H-benzo[g]indole 

Relevant academic research and scientific papers

A sustainable strategy for the straightforward preparation of 2H-azirines and highly functionalized NH-aziridines from vinyl azides using a single solvent flow-batch approach

The reported flow-batch approach enables the easy preparation of 2H-azirines and their stereoselective transformation into highly functionalized NH-aziridines, starting from vinyl azides and organolithium compounds. The protocol has been developed using c

Zn-ProPhenol Catalyzed Enantioselective Mannich Reaction of 2 H-Azirines with Alkynyl Ketones

The enantioselective Mannich reaction of 2H-azirines with alkynyl ketones is achieved under Zn-ProPhenol catalysis, delivering various aziridines with vicinal tetrasubstituted stereocenters in high yields with excellent enantioselectivities. The bimetalli

Visible-Light-Induced Regioselective C(sp3)-H Acyloxylation of Aryl-2 H-azirines with (Diacetoxy)iodobenzene

A visible-light-promoted regioselective coupling of C(sp3)-H of aryl-2H-azirine and (diacetoxy)iodobenzene has been reported. Rose Bengal as an organophotoredox catalyst has been used in this reaction. The reaction proceeds under aerobic condition at room temperature. A variety of aryl-2H-azirines gives the corresponding acyloxylated azirines under this reaction conditions. The reaction goes through a radical pathway. The protocol is also applicable on gram-scale synthesis.

Visible-Light Photoredox Catalyzed Three-Component Cyclization of 2H-Azirines, Alkynyl Bromides, and Molecular Oxygen to Oxazole Skeleton

A novel three-component cyclization of 2H-azirines, alkynyl bromides, and molecular oxygen under visible-light photoredox catalysis at room temperature has been developed, which provides a direct approach to a wide range of substituted oxazoles in moderate to good yields.

Exploiting the chemistry of strained rings: Synthesis of indoles via domino reaction of aryl iodides with 2 H-azirines

(Equation Presented). The highly strained 2H-azirine ring system has been the source of considerable theoretical and synthetic work. The reaction of these strained heterocycles with transition metals has been documented to give rise to ring opening and subsequent formation of varied heterocycles. An interesting domino reaction is described wherein the strained bicyclic alkene, norbornene, mediates the reaction of 2H-azirines with aryl iodides under palladium catalysis to provide indole or polycyclic dihydroimidazole heterocycles.