32687-39-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol is used as a building block in the synthesis of pharmaceuticals for its versatile properties and reactivity.
Used in Agrochemical Industry:
2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol is used as a building block in the synthesis of agrochemicals for its versatile properties and reactivity.
Used in Organic Synthesis:
2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol is used as a reagent in organic synthesis for its versatile properties and reactivity.
Used in Chemical Processes:
2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol is used as a solvent in some chemical processes for its versatile properties and reactivity.
Used in Antimicrobial and Antifungal Applications:
2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol is used in the development of new drugs and medical treatments for its antimicrobial and antifungal properties.

InChI:InChI=1/C9H8BrF3O/c10-5-8(14)6-1-3-7(4-2-6)9(11,12)13/h1-4,8,14H,5H2

Upstream product

• 383-53-9 2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone 

Downstream Products

• 5569-29-9 2-Cyclopropylamino-1-(4-trifluoromethyl-phenyl)-ethanol 
• 111991-14-1 2-(4-trifluoromethylphenyl)oxirane 
• 81561-66-2 2-hydroxy-2-(4-trifluoromethylphenyl)ethanamine 

Relevant academic research and scientific papers

RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE

Provided herein are compounds as RORγ antagonist having Formula (I). The compounds or pharmaceutical composition thereof can be used for regulating Retinoid-related orphan receptor gamma t (RORγt). Also provided herein are methods of preparation of the compounds and composition thereof, and uses thereof in treating or preventing RORγt mediated inflammation or autoimmune diseases in mammals, particularly humans.

Mechanistic investigations of cooperative catalysis in the enantioselective fluorination of epoxides

This report describes mechanistic studies of the (salen)Co- and amine-cocatalyzed enantioselective ring opening of epoxides by fluoride. The kinetics of the reaction, as determined by in situ 19F NMR analysis, are characterized by apparent first-order dependence on (salen)Co. Substituent effects, nonlinear effects, and reactivity with a linked (salen)Co catalyst provide evidence for a rate-limiting, bimetallic ring-opening step. To account for these divergent data, we propose a mechanism wherein the active nucleophilic fluorine species is a cobalt fluoride that forms a resting-state dimer. Axial ligation of the amine cocatalyst to (salen)Co facilitates dimer dissociation and is the origin of the observed cooperativity. On the basis of these studies, we show that significant improvements in the rates, turnover numbers, and substrate scope of the fluoride ring-opening reactions can be realized through the use of a linked salen framework. Application of this catalyst system to a rapid (5 min) fluorination to generate the unlabeled analog of a known PET tracer, F-MISO, is reported.