Shz-1, also known as 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide Benzenesulfonic Acid, is a sulfonylhydrazone compound that has the ability to activate cardiac differentiation in various stem and progenitor cells, including human mobilized peripheral blood mononuclear cells (M-PBMC). It is a cell permeable lead compound for the discovery of drugs that promote myocardial repair and regeneration.
326886-05-9
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Basic information
- Product Name: Shz-1
- Synonyms: Shz-1;2-[(5-BroMo-2-hydroxyphenyl)Methylene]hydrazide Benzenesulfonic Acid;Benzenesulfonic acid [(5-bromo-2-hydroxyphenyl)methylene]hydrazide;(E)-N-(5-bromo-2-hydroxybenzylidene)benzenesulfonohydrazide
- CAS NO:326886-05-9
- Molecular Formula: C13H11BrN2O3S
- Molecular Weight: 355.20704
- EINECS: N/A
- Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
- Mol File: 326886-05-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: ?20°C
- Solubility: DMSO: soluble10mg/mL, clear
- Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- CAS DataBase Reference: Shz-1(CAS DataBase Reference)
- NIST Chemistry Reference: Shz-1(326886-05-9)
- EPA Substance Registry System: Shz-1(326886-05-9)
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Safety Data
- Hazard Codes: Xi
- Statements: 36/37/38
- Safety Statements: 36/37/39
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 326886-05-9(Hazardous Substances Data)
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326886-05-9 Usage
Uses
Used in Pharmaceutical Industry:Shz-1 is used as a lead compound for the development of drugs that promote myocardial repair and regeneration by activating cardiac differentiation in M-PBMC.
Used in Regenerative Medicine:
Shz-1 is used as a cardiac differentiation activator for inducing the expression of early cardiac genes in mouse pluripotent and embryonic stem cells in vitro at low micromolar concentrations. This makes it a promising candidate for the advancement of regenerative medicine approaches to treat heart diseases and injuries.
References
1) Sadek?et al. (2008),?Cardiogenic small molecules that enhanced myocardial repair by stem cells; Proc. Natl. Acad. Sci. USA,?105?6063Check Digit Verification of cas no
The CAS Registry Mumber 326886-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,6,8,8 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.Calculate Digit Verification of CAS Registry Number 326886-05:
(8*3)+(7*2)+(6*6)+(5*8)+(4*8)+(3*6)+(2*0)+(1*5)=169
169 % 10 = 9
So 326886-05-9 is a valid CAS Registry Number.
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Shz-1
