326894-41-1Relevant academic research and scientific papers
Facile asymmetric synthesis of α-amino acids employing chiral ligand-mediated asymmetric addition reactions of phenyllithium with imines
Hasegawa, Masayoshi,Taniyama, Daisuke,Tomioka, Kiyoshi
, p. 10153 - 10158 (2007/10/03)
A three-step methodology involving an external chiral ligand-mediated asymmetric addition of phenyllithium to an anisidine imine, oxidative removal of N-PMP group, and finally oxidative conversion of the phenyl group to a carboxyl group provides a facile synthesis of optically pure α-amino acid derivatives beating a bulky α-substituent. (C) 2000 Elsevier Science Ltd.
