326903-67-7

Basic information

• Product Name: Acetamide, N-[4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-
• CAS NO: 326903-67-7
• Molecular Formula: C15H19N3O5S
• Molecular Weight: 353.399
• Mol File: 326903-67-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-(326903-67-7)
• EPA Substance Registry System: Acetamide, N-[4-acetyl-4,5-dihydro-5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]-(326903-67-7)

Safety Data

• Hazardous Substances Data: 326903-67-7(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 22043-16-9 (E)-2-(3,4,5-trimethoxybenzylidene)hydrazinecarbothioamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 116758-60-2 (5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl) acetamide D 

Relevant articles and documents

Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part 1. Transformation of N,S-acetals: 3-acyl-1,3,4-thiadiazolines

Aldehyde and ketone thiosemicarbazones are synthesized and cyclized into 3-acyl-1,3,4-thiadiazolines under acylating conditions. Reactions of the 2-monosubstituted heterocycles with oxidizing and dehydrogenating agents (KMnO4 or for the first time with CAN, DDQ, IBDA) lead to the formation of thiadiazoles. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-thiadiazolines regenerates the parent ketones efficiently.