326918-74-5

Upstream product

• 150-19-6 O-methylresorcine 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 1403826-32-3 ethyl (RS)-N-[(EZ)-4-(4-chlorophenyl)-3-cyano-7-methoxy-4H-chromen-2-yl]formimidate 

Downstream Products

• 1422739-84-1 C₁₈H₁₅ClN₄O₂ 
• 1422739-87-4 C₁₉H₁₃ClN₄O₂ 
• 1422739-89-6 C₂₀H₁₅ClN₄O₂ 
• 1422739-91-0 (RS)-ethyl 12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine-2-carboxylate 
• 1422739-94-3 C₂₁H₁₄ClN₅O₂ 
• 1422739-96-5 (RS)-2-(chloromethyl)-12-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1422739-97-6 (RS)-12-(4-chlorophenyl)-2-(3-chloropropyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1422740-00-8 (RS)-12-(4-chlorophenyl)-9-methoxy-2-phenyl-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1422740-01-9 (RS)-2,12-bis-(4-chlorophenyl)-9-methoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1422740-02-0 C₂₆H₁₉ClN₄O₃ 
• 1422740-04-2 (RS)-2,12-bis-(4-chlorophenyl)-9-ethoxy-12H-chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine 
• 1403826-32-3 ethyl (RS)-N-[(EZ)-4-(4-chlorophenyl)-3-cyano-7-methoxy-4H-chromen-2-yl]formimidate 
• 56822-11-8 4-(4-chlorophenyl)-7-methoxy-2-oxo-2H-chromene-3-carbonitrile 
• 1403826-34-5 (RS)-N'-(EZ)-(4-(4-chlorophenyl)-3-cyano-7-methoxy-4H-chromen-2-yl)-N-carbamothioyl formimidamide 

Relevant academic research and scientific papers

Synthesis and characterization of 11-amino-3-methoxy-8-substituted-12-aryl- 8,9-dihydro-7H-chromeno[2,3-b]quinolin-10(12H)-one derivatives

A series of 2-amino-7-methoxy-4-aryl-4H-chromene-3-carbonitrile compounds 2 were obtained by condensation of 3-methoxyphenol with β-dicyanostyrenes 1 in absolute ethanol containing piperidine. The intermediate enamines 3 were prepared by compounds 2 with

Synthesis of novel chromene derivatives of expected antitumor activity

Inhibition of tubulin polymerization is one of the important tactics in cancer therapy. Since 4-aryl-4H-chromene derivatives are found to be microtubule-binding agents via interfering with tubulin polymerization so we decide to concentrate our exploration efforts on the combination of this nucleus with 5-, 6-, and/or 7-memebered heterocyclic moieties in a novel series of compounds to explore the effect that might result from this combination. Ten novel compounds were selected for anticancer screening assay against MCF-7 breast cancer cell line in comparison to colchicine as positive control and most of them showed excellent activity.