326919-70-4

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 109-77-3 malononitrile 
• 22105-09-5 4‐hydroxycoumarin 

Relevant academic research and scientific papers

High-efficient synthesis of 2-imino-2H-chromenes and dihydropyrano[c]chromenes using novel and green catalyst (CaO@SiO2@AIL)

In this work, 1,3,5,7-tetraazaadamantan-1-ium chloride (AIL) functionalized silica-coated calcium oxide hybrid nanocatalyst (CaO@SiO2@AIL) as a novel, efficient, green and recyclable heterogeneous ionic liquid catalyst was synthesized. Catalytic activity of the CaO@SiO2@AIL hybrid nanoparticles was investigated for synthesis of the pharmaceutically valuable 2-imino-2H-chromene and dihydropyrano[c]chromene derivatives. A wide range of amines and aromatic aldehydes containing either electron-withdrawing or electron-donating substituent were examined using optimized conditions to produce the desired products. 2-Imino-2H-chromenes were synthesized under solvent-free condition, and dihydropyrano[c]chromenes were prepared in aqueous medium as green conditions within short reaction times, high yields and using easy workup procedures. Structure confirmation and surface properties of the core/shell hybrid nanoparticles were considered via Fourier transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscope, energy-dispersive X-ray spectroscopy, WDS map scan, thermogravimetric and elemental analyses. This IL-supported heterogeneous nanocatalyst can be reused at least six times without considerable loss of its performance.

Zn (II)-Schiff base covalently anchored to CaO@SiO2: A hybrid nanocatalyst for green synthesis of 4H-pyrans

In this study, the Zn (II)-Schiff base covalently anchored onto the surface of CaO@SiO2 nanoparticles. The structure of this hybrid nanomaterial (CaO@SiO2-NH2-Sal-Zn) was characterized using the analytical techniques such

Zr@IL-Fe3O4MNPs as an efficient and green heterogeneous magnetic nanocatalyst for the one-pot three-component synthesis of highly substituted pyran derivatives under solvent-free conditions

The present study was conducted to synthesize Zr@IL-Fe3O4MNPs as a new magnetically recoverable heterogeneous catalyst, which was then characterized by Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray spectros

Ionic liquid-promoted one-pot method for synthesizing 4H-pyranocoumarin derivatives

The invention discloses ionic liquid-promoted one-pot method for synthesizing 4H-pyranocoumarin derivatives. The method comprises the steps of performing a reaction under stirring for 0.5-12 h by using 4-hydroxycoumarin, one aromatic aldehyde compound and

Efficient synthesis of 2-amino-3-cyano-4H-pyran derivatives via a non-catalytic one-pot three-component reaction

Abstract: A convenient one-pot multi-component strategy was conducted successfully under catalyst-free conditions employing water and PEG-400 as the efficient and cheap promoting medium. Three types and nearly 50 2-amino-3-cyano-4H-pyran annulated derivat

Screening of a library of 4-aryl/heteroaryl-4H-fused pyrans for xanthine oxidase inhibition: Synthesis, biological evaluation and docking studies

A series of 4-aryl/heteroaryl-4H-fused pyrans was synthesized via multicomponent reaction in a microwave synthesizer. All the pyrans were evaluated for in vitro xanthine oxidase inhibition. Structure-activity relationship was also established. Among the s

Crown ether complex cation ionic liquids (CECILs) as environmentally benign catalysts for three-component synthesis of 4,5-dihydropyrano[3,2-c]chromene and 4,5-dihydropyrano[4,3-b]pyran derivatives

Crown ether complex cation ionic liquids (CECILs) catalyze three-component reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin or 4-hydroxy-6-methylpyrone, in EtOH under reflux, for synthesis of 4,5-dihydropyrano[3,2-c]chromene and 4,5-di

Highly efficient three-component, one-pot synthesis of dihydropyrano[3,2-c] chromene derivatives

An efficient and convenient method for synthesis of dihydropyrano[3,2-c] chromene derivatives by onepot, three-component reaction of aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of a catalytic amount of hexamethylenetetramine is reporte