327021-84-1

Basic information

• Product Name: CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO-
• Synonyms: CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO-;7-Fluoro-1,2,3,4-tetrahydrocyclopent[b]indole
• CAS NO: 327021-84-1
• Molecular Formula: C₁₁H₁₀FN
• Molecular Weight: 175.2
• Mol File: 327021-84-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 304.7±37.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.99±0.20(Predicted)
• CAS DataBase Reference: CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO-(327021-84-1)
• EPA Substance Registry System: CYCLOPENT[B]INDOLE, 7-FLUORO-1,2,3,4-TETRAHYDRO-(327021-84-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 327021-84-1(Hazardous Substances Data)

Usage

General Description

7-fluoro-1,2,3,4-tetrahydrocyclopent[b]indole is a chemical compound belonging to the class of organic compounds known as tetrahydroindoles. These compounds are indoles that are tetrasubstituted at one carbon atom within the indole group, with a fluorine atom located at the seventh position. This specific compound is also categorized as a 1,2,3,4-tetrahydroindole which means it consists of a ring system of cyclopent[b]indole where the five-membered ring is fully saturated and the indolyl portion has one double bond remaining with an additional fluorine atom. This chemical is not frequently found which makes it exclusive for certain specialized applications. Its properties like solubility, toxicity, or bioactivity can vary depending on its derivative groups.

Upstream product

• 371-14-2 4-fluorophenylhydrazine 
• 120-92-3 cyclopentanone 

Relevant articles and documents

Pd-Catalyzed Dearomatization of Indole Derivatives via Intermolecular Heck Reactions?

Pd-catalyzed intermolecular dearomative Heck reaction of indoles with aryl iodides is described. The challenges on both reactivity and regioselectivity are addressed by the judicious regulation of the geometric and electronic properties of the substrates. An array of indoline derivatives bearing C2-quaternary center is obtained in good to excellent yields (up to 93%) with exclusive regioselectivity under operationally simple conditions. The mechanistic proposal is supported by detailed DFT calculations.

Indole derivatives process for their preparation, pharmaceutical compositions containing them and their medicinal application

A chemical compound of formula (I) wherein: R1and R2are independently selected from hydrogen and alkyl; R3is alkyl; R4, R6and R7are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsufoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; R5is selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; A is a 5- or 6-membered partially unsaturated or aromatic heterocyclic ring or a 5- or 6-membered partially unsaturated carbocyclic ring, wherein if A is a 6-membered partially unsaturated carbocyclic ring then at least one of R4to R7is other than hydrogen, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof, and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2Creceptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinial disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.