327025-10-5

Basic information

• Product Name: (2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate
• Synonyms: (2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate
• CAS NO: 327025-10-5
• Molecular Weight: 383.442
• Mol File: 327025-10-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate(327025-10-5)
• EPA Substance Registry System: (2S)-methyl-[2-tert-butoxycarbonylamino-4-(3,4,5-trimethoxyphenyl)]butanoate(327025-10-5)

Safety Data

• Hazardous Substances Data: 327025-10-5(Hazardous Substances Data)

Upstream product

• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 327025-09-2 (2S)-methyl-[2-tert-butoxycarbonylamino-4-oxo-4-(3,4,5-trimethoxyphenyl)]butanoate 

Downstream Products

• 327025-13-8 (2S)-methyl-[2-acetamido-4-(2-trimethylsilylethynyl-3,4,5-trimethoxyphenyl)]butanoate 
• 206195-35-9 (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(5-oxazolyl)propylamine 
• 327025-14-9 (2S)-methyl-[2-acetamido-4-(2-ethynyl-3,4,5-trimethoxyphenyl)]butanoate 
• 327025-12-7 (2S)-methyl-[2-acetamido-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate 
• 1058131-94-4 N-[3-(2-ethynyl-3,4,5-trimethoxy-phenyl)-1-formyl-propyl]-acetamide 
• 64-86-8 colchicine 
• 327025-11-6 (2S)-methyl-[2-tert-butoxycarbonylamino-4-(2-iodo-3,4,5-trimethoxyphenyl)]butanoate 

Relevant articles and documents

Total synthesis of (-)-colchicine by an oxyallyl [4 + 3] cycloaddition

An enantioselective synthesis of (-)-colchicine, free from isocolchicine, is delineated and features tandem application of the intramolecular Diels-Alder reaction of acetylene-tethered oxazoles and the [4+3] cycloaddition of oxyallyls. This work underscores the synthetic utility of little explored α-alkoxy substituted oxyallyls. (C) 2000 Elsevier Science Ltd.