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(2R)-6-CHLORO-2-METHYL-8-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE is a chemical compound with the molecular formula C9H6ClNO4. It is a derivative of benzoxazinone, a class of organic compounds with a heterocyclic structure. This particular compound contains a chlorine atom, a methyl group, and a nitro group attached to the benzoxazinone ring. It is used in organic synthesis and pharmaceutical research as a building block for the synthesis of more complex molecules. The presence of the chlorine, methyl, and nitro groups on the benzoxazinone ring provides unique reactivity and properties, making it useful for various chemical applications.
Used in Organic Synthesis:
(2R)-6-CHLORO-2-METHYL-8-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE is used as a building block for the synthesis of more complex molecules. Its unique reactivity and properties, due to the presence of the chlorine, methyl, and nitro groups on the benzoxazinone ring, make it a valuable component in the creation of advanced organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (2R)-6-CHLORO-2-METHYL-8-NITRO-2H-1,4-BENZOXAZIN-3(4H)-ONE serves as a key intermediate in the development of new drugs. Its distinctive chemical structure allows researchers to explore its potential in creating novel therapeutic agents, particularly those targeting specific biological pathways or mechanisms.

327026-91-5

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327026-91-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 327026-91-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,0,2 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 327026-91:
(8*3)+(7*2)+(6*7)+(5*0)+(4*2)+(3*6)+(2*9)+(1*1)=125
125 % 10 = 5
So 327026-91-5 is a valid CAS Registry Number.

327026-91-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-6-chloro-2-methyl-8-nitro-4H-1,4-benzoxazin-3-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:327026-91-5 SDS

327026-91-5Relevant academic research and scientific papers

PHENYLPIPERAZINES AS SEROTONIN REUPTAKE INHIBITORS

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Page/Page column 6; 8-9, (2008/06/13)

The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances

Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[ω-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition

Smid, Pieter,Coolen, Hein K. A. C.,Keizer, Hiskias G.,Van Hes, Rolf,De Moes, Jan-Peter,Den Hartog, Arnold P.,Stork, Bob,Plekkenpol, Rob H.,Niemann, Leonarda C.,Stroomer, Cees N. J.,Tulp, Martin Th. M.,Van Stuivenberg, Herman H.,McCreary, Andrew C.,Hesselink, Mayke B.,Herremans, Arnoud H. J.,Kruse, Chris G.

, p. 6855 - 6869 (2007/10/03)

A series of novel bicyclic 1-heteroaryl-4-[ω-(1H-indol-3-yl)alkyl] piperazines was synthesized and evaluated on binding to dopamine D2 receptors and serotonin reuptake sites. This class of compounds proved to be potent in vitro dopamine D2 receptor antagonists and in addition were highly active as serotonin reuptake inhibitors. Some key representatives showed potent pharmacological in vivo activities after oral dosing in both the antagonism of apomorphine-induced climbing and the potentiation of 5-HTP-induced behavior in mice. On the basis of the preclinical data, 8-{4-[3-(5-fluoro-1H- indol-3-yl)propyl]piperazin-1-yl}-4H-benzo[1,4]oxazin-(R)-2-methyl-3-one (45c, SLV314) was selected for clinical development. In vitro and in vivo studies revealed that 45c has favorable pharmacokinetic properties and a high CNS plasma ratio. Molecular modeling studies showed that the bifunctional activity of 45c can be explained by its ability to adopt two different conformations fitting either the dopamine D2 receptor pharmacophore or the serotonin transporter pharmacophore.

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