327027-84-9

Upstream product

• 75-11-6 diiodomethane 
• 327027-83-8 (3Z,9E)-(1R,7S,11S,15R,17R)-11-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxymethyl)-15-methyl-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,19-triene-5,13-dione 
• 124655-05-6 (S)-methyl 4-(tert-butyldiphenylsilyloxy)-3-hydroxybutanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 327027-78-1 (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid 
• 327027-77-0 (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-(4-methoxy-benzyloxy)-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid methyl ester 
• 327027-81-6 (Z)-4-{(2R,6S)-6-[(2E,7E)-(S)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-hydroxy-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid 
• 327027-79-2 (Z)-4-{(2R,6S)-6-[(2E,7E)-(R)-6-(tert-Butyl-dimethyl-silanyloxy)-11-(tert-butyl-diphenyl-silanyloxy)-10-hydroxy-4-oxo-undeca-2,7-dienyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-enoic acid 
• 327027-69-0 (3Z,9E,14E)-(1R,7S,11S,17S)-11-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxymethyl)-6,21-dioxa-bicyclo[15.3.1]henicosa-3,9,14,19-tetraene-5,13-dione 
• 693790-04-4 (S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyric acid methyl ester 
• 478491-16-6 (3S)-4-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy) butyraldehyde 
• 327027-70-3 (Z)-4-[(2R,6S)-6-((E)-4-Oxo-pent-2-enyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-enoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of the macrocyclic core of laulimalide

equation presented A stereoselective synthesis of 3, corresponding to the fully functionalized macrocyclic core of the novel microtubule-stabilizing agent, laulimalide, has been completed. Efficient macrolactonization was achieved by a Mitsunobu reaction,