327031-55-0 Usage
Uses
Used in Oncology:
2-[1-(2-6-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-ylhydrazine-1-ylidene)ethyl]pyridine is used as a cytotoxic agent for cancer cells, specifically targeting malignant cells and inducing necrosis in colon cancer cells. Its selective cytotoxicity and ability to stimulate autophagy and trigger mitochondrial dysfunction make it a promising candidate for the development of anticancer therapies.
Used in Cancer Research:
In the field of cancer research, 2-[1-(2-6-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-ylhydrazine-1-ylidene)ethyl]pyridine serves as a valuable tool for studying the mechanisms underlying its selective cytotoxicity against quiescent cancer cells and its effects on gene expression, autophagy, and mitochondrial dysfunction. This knowledge can contribute to the development of novel therapeutic strategies for cancer treatment.
Used in Drug Development:
2-[1-(2-6-methyl-5H-[1,2,4]triazino[5,6-b]indole-3-ylhydrazine-1-ylidene)ethyl]pyridine is utilized in drug development as a potential lead compound for the creation of new anticancer drugs. Its unique properties, such as selective cytotoxicity and minimal systemic toxicity, make it an attractive candidate for further optimization and development into a therapeutic agent for the treatment of colon cancer and potentially other types of cancer.
references
zhang x, frykns m, hernlund e, et al. induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. nat commun. 2014;5:3295.
Check Digit Verification of cas no
The CAS Registry Mumber 327031-55-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,0,3 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 327031-55:
(8*3)+(7*2)+(6*7)+(5*0)+(4*3)+(3*1)+(2*5)+(1*5)=110
110 % 10 = 0
So 327031-55-0 is a valid CAS Registry Number.
327031-55-0Relevant academic research and scientific papers
PHARMACEUTICAL COMPOSITION COMPRISING INDOLE DERIVATIVES, PROCESS FOR PREPARATION AND USE THEREOF
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, (2017/07/06)
The invention provides well-defined and stable pharmaceutical compositions comprising indole derivatives of general formula 1, a process for the preparation of di-hydrochloride salts comprising a high content of the pharmacologically active isomer suitable for industrial production, and use of these in pharmaceutical compositions. The invention further provides a method for use of said compounds for the treatment of cancer. The invention also provides methods to use these compounds in conjunction with other therapies commonly used for treating cancer diseases.
