327039-79-2

Upstream product

• 880498-23-7 C₃₆H₅₄O₇ 
• 880498-24-8 C₃₂H₄₆O₅ 
• 72652-35-8 1,3-bis-bromomethyl-2,5-dimethoxy-benzene 

Downstream Products

• 880498-26-0 (4S,9S,17S,22S)-(+)-9,17-bis(3,5-dimethylphenyl)-3,10,13,16,23-pentaoxatetracyclo[23.3.1.0^4,9.0^17,22]nonacosa-25,28-diene-27,29-dione 
• 880498-25-9 (4S,9S,17S,22S)-(+)-29-hydroxy-27-methoxy-9,17-bis(3,5-dimethylphenyl)-3,10,13,16,23-pentaoxatetracyclo[23.3.1.0^4,9.0^17,22]nonacosa-1⁽²⁹⁾,25,27-triene 

Relevant academic research and scientific papers

Remaekable effect of subtle structural change of chiral pseudo-18-crown-6 on enantiomer-selectivity in complexation with chiral amino alcohols

Chiral receptors [(S,S)-1] and [(S,S,S,S)-2] having 1,2-dialkoxy-1-(3,5-dimethylphenyl)ethane and 1,2-dialkoxy-1-(3,5-dimethyl phenyl)cyclohexane as chiral building blocks, respectively, were prepared. Thermodynamic parameters of complexations of these and structurally related receptors [(S,S)-3] and [(S,S,S,S)-4] with 2-amino-l-propanol (5), 2-amino-2-phenylethanol (6), and 3-methylbutan-l-ol (7) in chloroform were determined. It was found that the host-guest systems that have same enantiomer-selectivity at 25°C showed opposite selectivity in the enthalpy term. For example, complexations of both (S,S)-1 and (S,S)-3 with 5 are R-selective at 25°C (ΔΔG = 2.2 and 3.8 kJ mol-1, respectively), whereas in terms of the enthalpy of complexation the former is S-selective (ΔΔH = 22 kJ mol-1) but the latter is R-selective (ΔΔH = 10 kJ mol-1).