327070-54-2Relevant academic research and scientific papers
An efficient and atom-economical route to: N -aryl amino alcohols from primary amines
Xiao, Zhen,Li, Juanjuan,Yue, Qiang,Zhang, Qian,Li, Dong
, p. 34304 - 34308 (2018/10/24)
In this paper we reported a novel method for generation of N-aryl amino alcohols from N,N-disubstituted picolinamides through reduction/ring-opening reaction with NaBH4. The N,N-disubstituted picolinamides can be easily obtained from primary am
Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association
Barthel, Alexander,Trieschmann, Lothar,Stroehl, Dieter,Kluge, Ralph,Boehm, Gerald,Csuk, Rene
experimental part, p. 445 - 452 (2009/12/05)
The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Aβ peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.
