327072-88-8Relevant academic research and scientific papers
Facile synthesis, characterization and antimicrobial activity of 2-alkanamino Benzimidazole derivatives
Ajani, Olayinka O.,Aderohunmu, Damilola V.,Olorunshola, Shade J.,Ikpo, Chinwe O.,Olanrewaju, Ifedolapo O.
, p. 109 - 120 (2016/05/09)
Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV, 1H-NMR, 13C-NMR, Mass spectral and analytical data. The compounds were investigated for their antimicrobial activity alongside gentamicin clinical standard. The results showed that this skeletal framework exhibited marked potency as antimicrobial agents. The most active compound was 1H-benzo[d]imidazol-2-yl)methanamine, 10a.
Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors
Korkmaz, Neslihan,Obaidi, Oday A.,Senturk, Murat,Astley, Demet,Ekinci, Deniz,Supuran, Claudiu T.
, p. 75 - 80 (2015/03/03)
A new series of chiral thiourea derivatives (5a-5c) and thiourea containing benzimidazole moieties (9b-9e) were synthesized from different amino acids (L-valine, L-isoleucine, L-methionine, L-phenylalanine, and D-phenylglycine). The compounds were charact
Synthesis of benzimidazoles from amino acids with solvent-free melting method
Chen, Ren-Hong,Xiong, Jin-Feng,Peng, Pai,Mo, Guang-Zhen,Tang, Xing-San,Wang, Zhao-Yang,Wang, Xiu-Fang
, p. 926 - 932 (2014/06/09)
By using low cost and readily available amino acids as the synthetic blocks, a series of 2-Aminomethyl-benzimidazole are synthesized with solvent-free melting method. While the condensation of aspartic acid (or asparagine) with o-diaminobenzene gives the
Discovery of small molecule human FPR1 receptor antagonists
Unitt, John,Fagura, Malbinder,Phillips, Tim,King, Sarah,Perry, Matthew,Morley, Andrew,MacDonald, Cathy,Weaver, Richard,Christie, Jadeen,Barber, Simon,Mohammed, Rukhsana,Paul, Melanie,Cook, Andrew,Baxter, Andrew
, p. 2991 - 2997 (2011/06/24)
The identification of two novel series of formyl peptide receptor 1 (FPR1) antagonists are reported, represented by methionine benzimidazole 6 and diamide 7. Both series specifically inhibited the binding of labelled fMLF to hrFPR1 and selectively antagonized FPR1 function in human neutrophils, making them useful in vitro validation tools for the target.
