327085-11-0Relevant academic research and scientific papers
DNA/protein binding and cytotoxicity studies of copper(ii) complexes containing N,N′,N′′-trisubstituted guanidine ligands
Jeyalakshmi, Kumaramangalam,Selvakumaran, Nagamani,Bhuvanesh, Nattamai S. P.,Sreekanth, Anantharaman,Karvembu, Ramasamy
, p. 17179 - 17195 (2014)
A series of N,N′,N′′-trisubstituted guanidine ligands (L1-L5) and their copper(ii) complexes (1-5) [Cu(ii){C4H 3SCONC(NHR)NC6H5}2] [where R = p-tolyl (1), phenyl (2) benzyl (3), butyl (4) and cyclohexyl (5)] were synthesized and characterized by elemental analyses and UV-visible, FT-IR, 1H & 13C NMR/EPR and mass spectroscopic techniques. The molecular structure of L1-L5, 3, and 5 was confirmed by single crystal X-ray crystallography. The single crystal X-ray structure of the complexes reveals the square planar geometry. The interaction of calf thymus DNA (CT-DNA) and bovine serum albumin (BSA) with the copper(ii) complexes was investigated using UV-visible and fluorescence spectrophotometric methods. Spectral evidence shows the intercalative mode of DNA binding (in the order of 104 M -1) with the complexes. The Stern-Volmer quenching constant (K q) values were found from competitive binding studies and found to be in the range of 1.07-1.30 × 105 M-1 for the complexes. Spectral evidence also shows good binding properties of the complexes with the protein. Complexes 3 and 4 showed significant cytotoxicity against human breast (MCF7) and lung cancer (A549) cell lines.
