327096-53-7Relevant academic research and scientific papers
Stereoselective synthesis of 3,4-disubstituted pyroglutamates by ring transformation of 5-ylidene-1,3-dioxan-4-ones with N-(diphenylmethylene)-glycinate
Ali, Akbar,Uddin Ahmad, Viqar,Ziemer, Burkhard,Liebscher, Juergen
, p. 4365 - 4375 (2007/10/03)
N-(Diphenylmethylene)-glycinate gives stereoselective conjugate addition to readily available (E) and (Z)-5-ylidene-1,3-dioxan-4-ones. Hydrolytic cleavage of the imine functionality of the resulting Michael-adducts causes ring transformation to new, optically active 3,4-disubstituted pyroglutamates. (C) 2000 Elsevier Science Ltd.
