327163-77-9

Upstream product

• 208986-13-4 methyl 2-amino-3,6-dimethoxybenzoate 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 327163-76-8 methyl 3,6-dimethoxy-2-nitrobenzoate 

Downstream Products

• 327164-05-6 (2-bromo-3,6-dimethoxyphenyl)methanol 
• 327163-83-7 methyl 3,6-dimethoxy-2-(dimethoxymethyl)-4-(2-propenyl)benzoate 
• 327163-84-8 [2-(dimethoxymethyl)-3,6-dimethoxy-4-(2-propenyl)phenyl]methanol 
• 327163-82-6 1-bromo-2-(dimethoxymethyl)-3,6-dimethoxy-4-(2-propenyl)benzene 
• 327163-80-4 2-bromo-6-hydroxy-3-methoxy-5-(2-propenyl)benzaldehyde 
• 327163-81-5 2-bromo-3,6-dimethoxy-5-(2-propenyl)benzaldehyde 
• 327163-79-1 2-bromo-3-methoxy-6-(2-propenyloxy)benzaldehyde 
• 327163-78-0 2-bromo-6-hydroxy-3-methoxybenzaldehyde 
• 85432-87-7 2-bromo-3,6-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

ENHANCING AUTOPHAGY OR INCREASING LONGEVITY BY ADMINISTRATION OF UROLITHINS OR PRECURSORS THEREOF

Disclosed are methods, compounds, and compositions useful for increasing autophagy and promoting longevity. The methods, compounds, and compositions relate to urolithins and urolithin precursors and use thereof. Certain urolithins are represented by Formula I, while certain urolithin precursors are represented by Formula IV. The urolithin may be urolithin A, urolithin B, urolithin C, or urolithin D. The urolithin precursor may be ellagic acid or an ellagitannin. The methods include in vivo, ex vivo, and in vitro uses of the compounds and compositions.

Synthesis of (+/-)-puraquinonic acid: an inducer of cell differentiation.

Puraquinonic acid (1) was synthesized from 2,5-dimethoxybenzoic acid by way of isochroman 2 and the indanone derivative 3, a Nazarov cyclization being used to construct the five-membered ring.