32738-09-3

Usage

Chemical Properties

Solid

InChI:InChI=1/C10H14N2O5S/c1-4-2-12(10(18)11-8(4)16)9-7(15)6(14)5(3-13)17-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,18)

Upstream product

• 75921-08-3 O^2'_,O3'_,O5'-tribenzoyl-5-methyl-2-thio-uridine 
• 7408-41-5 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl azide 

Downstream Products

• 122146-67-2 5-methyl-O^5'-trityl-2-thio-uridine 
• 124290-35-3 (9aR)-3c-hydroxy-7-methyl-2t-trityloximethyl-(3ac.9ar)-2,3,3a,9a-tetrahydro-furo[2',3':4,5]thiazolo[3,2-a]pyrimidin-6-one 

Relevant academic research and scientific papers

Fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA

We report herein comprehensive investigations of alkylation/sulfur exchange reactions of sulfur-containing substrates including nucleosides such as s2U, m5s2U, s4U, s2A and s2T-incorporated DNA enable by comprehensive screenings of the reagents (2a–2h). It has been proven that iodoacetamide (2a) displays the most promising feasibility toward sulfur-containing substrates including s2T, s2U, m5s2U, s4U and s2A. In sharp contrast, the alkylation process with S-benzyl methanethiosulfonate (BMTS, 2h) displays the best application potential only for s4U. Based on these results, the fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA has been achieved. Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1942044.

Compounds and oligomeric compounds comprising novel nucleobases

The present invention relates to nucleoside compositions comprising novel nucleobases and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity properties compared to oligomeric compounds without the modification. The oligomeric compounds are useful, for example, for investigative and therapeutic purposes.