32741-05-2

Basic information

• Product Name: 2-Isobutylthiophene
• Synonyms: 2-(2-Methylpropyl)thiophene;2-Isobutylthiophene;2-isobutylthiophene:2-(2-methylpropyl)thiophene
• CAS NO: 32741-05-2
• Molecular Formula: C₈H₁₂S
• Molecular Weight: 140.25
• Mol File: 32741-05-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: -56.9°C (estimate)
• Boiling Point: 174 °C
• Flash Point: 40 °C
• Appearance: /
• Density: 0.966
• Vapor Pressure: 1.64mmHg at 25°C
• Refractive Index: 1.4982
• CAS DataBase Reference: 2-Isobutylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isobutylthiophene(32741-05-2)
• EPA Substance Registry System: 2-Isobutylthiophene(32741-05-2)

Safety Data

• Hazardous Substances Data: 32741-05-2(Hazardous Substances Data)

Usage

Description

2-Isobutylthiophene, with the molecular formula C10H14S, is a colorless to pale yellow liquid characterized by a strong, pungent odor. It is a chemical compound known for its distinctive sulfurous scent and is utilized in various industries for its aromatic properties.

Uses

Used in the Food Industry:
2-Isobutylthiophene is used as a flavoring agent for its strong, pungent, and sulfurous odor and taste, enhancing the sensory experience of various food products.
Used in the Fragrance Industry:
This chemical compound serves as a key ingredient in the production of fragrances, leveraging its strong and distinctive aromatic properties to contribute to the overall scent profile of perfumes and other scented products.
Used in Pharmaceutical Synthesis:
2-Isobutylthiophene is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs and medicinal compounds.
Used in the Agricultural and Pesticide Industries:
Due to its strong odor and aromatic properties, 2-Isobutylthiophene is employed in the manufacturing of agricultural products and insecticides, where its pungent characteristics can be advantageous for pest control and other applications.
However, it is important to note that exposure to 2-Isobutylthiophene should be limited, as it can cause irritation to the skin, eyes, and respiratory system, and may have adverse effects on human health if not handled properly.

InChI:InChI=1/C8H12S/c1-7(2)6-8-4-3-5-9-8/h3-5,7H,6H2,1-2H3

Upstream product

• 188290-36-0 thiophene 
• 78-77-3 Isobutyl bromide 
• 513-38-2 Isobutyl iodide 
• 36448-60-9 2-methyl-1-thiophen-2-yl-propan-1-one 

Downstream Products

• 84702-96-5 1-(5-isobutylthiophen-2-yl)ethanone 
• 104804-16-2 5-isobutylthiophene-2-carbaldehyde 
• 113411-25-9 5-isobutylthiophene-2-sulfonamide 
• 397-90-0 2-(4-fluoro-phenyl)-3c-(5-isobutyl-[2]thienyl)-acrylonitrile 
• 5681-91-4 5-isobutyl-thiophene-2-carboxylic acid 

Relevant articles and documents

Selective angiotensin II AT2 receptor agonists: Arylbenzylimidazole structure-activity relationships

Structural alterations in the 2- and 5-positions of the first drug-like selective angiotensin II AT2 receptor agonist (1) have been performed. The imidazole ring system was proven to be a strong determinant for the AT2 selectivity, and with few exceptions all variations gave good AT2 receptor affinities and with retained high AT 2/AT1 selectivities. On the contrary to the findings with AT1 receptor agonists, the impact of structural modifications in the 5-position of the AT2 selective compounds were less pronounced regarding activation of the AT2 receptor. The butyloxyphenyl (56) and the propylthienyl (50) derivatives were found to exert a high agonistic effect as deduced from their capacity to induce neurite elongation in neuronal cells, as does angiotensin II.

N-acyl sulfamide FBPase inhibitor, preparation method thereof, drug composition and application

The invention discloses an N-acryl sulfamide FBPase inhibitor of a novel structure, and a preparation method thereof, a drug composition and an application, and particularly relates to an N-acryl sulfamide FBPase inhibitor shown in the formula I, a salt thereof for medicine, a preparation method, a composition comprising one or more compounds, an application of the compound in preparing the FBPase inhibitor or a drug for treating FBPase-related diseases, and an application in preparing a drug for preventing and/or treating diabetes. The formula is shown in the description.

New FBPase inhibitors for diabetes

Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.