32741-11-0

Usage

Uses

Used in Food and Beverage Industry:
2-TERT-BUTYLPYRAZINE is used as a flavoring agent for its aromatic and savory characteristics, enhancing the taste and aroma of various food and beverage products.
Used in Fragrance Production:
2-TERT-BUTYLPYRAZINE is used as a component in the production of fragrances, contributing to the creation of complex and appealing scents.
Used in Organic Synthesis:
2-TERT-BUTYLPYRAZINE is used as a precursor in the synthesis of various organic compounds, playing a crucial role in the development of new chemical products.

InChI:InChI=1/C8H12N2/c1-8(2,3)7-6-9-4-5-10-7/h4-6H,1-3H3

Upstream product

• 290-37-9 1,4-pyrazine 
• 35448-10-3 oxalic acid mono-tert-butyl ester 
• 75-98-9 Trimethylacetic acid 
• 594-19-4 tert.-butyl lithium 

Downstream Products

• 1201763-08-7 C₈H₁₄N₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-) 

Relevant academic research and scientific papers

New lithium-zincate approaches for the selective functionalisation of pyrazine: Direct dideprotozincation vs. nucleophilic alkylation

Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)tBu2] (1) and [(PMDETA)LiZn tBu3] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C-H alkylation of this sensitive heterocycle.

A Novel, Simple and Cheap Source of Alkyl Radicals from Alcohols, Useful for Heterocyclic Substitution

Alkyl radicals were easily produced from secondary or tertiary alcohols in a cheap and simple way by silver-catalyzed decarboxylation of oxalic acid monoesters by S2O8(2-).They were utilized for the alkylation of heteroaromatic bases in a two-phase system, with high yields and selectivity.

Homolytic alkylation of heteroaromatic bases : The problem of monoalkylation

The silver-catalyzed decarboxylation of carboxylic acids by persulphate leads to alkyl radicals, which have been utilized for the selective alkylation of heteroaromatic bases. The method is particularly efficient in a water-chlorobenzene two-phase system for two reasons : it considerably increases the selectivity in monoalkylation when more positions of high nucleophilic reactivity (i.e. α and γ) are available in the heterocyclic ring (i.e. quinoline , 4-cyano- and 4-ethylpyridine, pyrazine , quinoxaline etc.) and it determines a much higher efficiency for the radical sources when the silver salt catalysis is deactivated by complexation of the salt with the heterocyclic compound . The high selectivity in monoalkylation has been obtained by the combination of polar effects and the increased lipophilicity of the alkylated product, which makes its extraction from the aqueous solution by the organic solvent easier.