32741-11-0

Basic information

• Product Name: 2-TERT-BUTYLPYRAZINE
• Synonyms: (1,1-dimethylethyl)-pyrazin;(1,1-Dimethylethyl)pyrazine;(1,1-dimethylethyl)-Pyrazine;Pyrazine,(1,1-dimethylethyl)-;2-TERT-BUTYLPYRAZINE;2-T-BUTYLPYRAZINE;tert-butylpyrazine;2-tert-Butylpyrazine
• CAS NO: 32741-11-0
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• EINECS: 251-186-7
• Mol File: 32741-11-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 179.9 °C at 760 mmHg
• Flash Point: 66.6 °C
• Appearance: /
• Density: 0.955 g/cm³
• Vapor Pressure: 1.25mmHg at 25°C
• Refractive Index: 1.4870-1.4910
• PKA: 1.79±0.10(Predicted)
• CAS DataBase Reference: 2-TERT-BUTYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTYLPYRAZINE(32741-11-0)
• EPA Substance Registry System: 2-TERT-BUTYLPYRAZINE(32741-11-0)

Safety Data

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 32741-11-0(Hazardous Substances Data)

Usage

General Description

2-Tert-butylpyrazine is a chemical compound with a molecular formula C8H12N2. It is a colorless to yellow liquid with a strong nutty, roasted, and toasted odor. This chemical is commonly used as a flavoring agent in food and beverages due to its aromatic and savory characteristics. It is also used in the production of fragrances and as a precursor in the synthesis of various organic compounds. 2-Tert-butylpyrazine is considered safe for use in food and has been approved by the US Food and Drug Administration as a flavoring substance. However, it should be handled with care and proper safety precautions as it can be harmful if ingested or inhaled in large quantities.

InChI:InChI=1/C8H12N2/c1-8(2,3)7-6-9-4-5-10-7/h4-6H,1-3H3

Upstream product

• 290-37-9 1,4-pyrazine 
• 35448-10-3 oxalic acid mono-tert-butyl ester 
• 75-98-9 Trimethylacetic acid 
• 594-19-4 tert.-butyl lithium 

Downstream Products

• 1201763-08-7 C₈H₁₄N₃⁽¹⁺⁾*C₉H₁₁O₃S^(1-) 

Relevant articles and documents

New lithium-zincate approaches for the selective functionalisation of pyrazine: Direct dideprotozincation vs. nucleophilic alkylation

Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)tBu2] (1) and [(PMDETA)LiZn tBu3] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C-H alkylation of this sensitive heterocycle.

Homolytic alkylation of heteroaromatic bases : The problem of monoalkylation

The silver-catalyzed decarboxylation of carboxylic acids by persulphate leads to alkyl radicals, which have been utilized for the selective alkylation of heteroaromatic bases. The method is particularly efficient in a water-chlorobenzene two-phase system for two reasons : it considerably increases the selectivity in monoalkylation when more positions of high nucleophilic reactivity (i.e. α and γ) are available in the heterocyclic ring (i.e. quinoline , 4-cyano- and 4-ethylpyridine, pyrazine , quinoxaline etc.) and it determines a much higher efficiency for the radical sources when the silver salt catalysis is deactivated by complexation of the salt with the heterocyclic compound . The high selectivity in monoalkylation has been obtained by the combination of polar effects and the increased lipophilicity of the alkylated product, which makes its extraction from the aqueous solution by the organic solvent easier.