327593-02-2Relevant academic research and scientific papers
Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones
Gupton, John T.,Crawford, Evan,Mahoney, Matt,Clark, Evan,Curry, Will,Lane, Annie,Shimozono, Alex,Moore-Stoll, Veronica,Elofson, Kristen,Juekun, Wen,Newton, Micah,Yeudall, Scott,Jaekle, Elizabeth,Kanters, Rene,Sikorski, James A.
, p. 7408 - 7420 (2018/11/23)
Pyrroles and quinolones represent core structures, which are routinely found in both natural and synthetic bioactive substances. Consequently, the development of efficient and regiospecific methods for the preparation of such heterocycles with unique functionality is of some importance. We describe herein the regiospecific synthesis of 1,2,3,4-tetrasubstituted pyrroles containing polar substituents and such products are prepared from vinylogous carbamates and vinylogous aminonitriles. We also describe the regiospecific synthesis of 3-aryl containing 1,3,6-trisubstituted quinolones from vinylogous carbamates. The use of an amine exchange reaction to prepare precursors for the pyrrole and quinolone forming cyclizations represents a key factor in the strategy.
Pharmaceutical compositions comprising 4-quinolones for treating cancers
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, (2008/06/13)
A non-cytotoxic pharmaceutical composition acting on the proliferation of clonogenic cells in malignant tumors and including an efficient amount of a compound selected among the compounds of formula (I) and (Ia).
