327596-79-2Relevant academic research and scientific papers
A novel protecting strategy for internucleosidic phosphate and phosphorothioate groups
Guzaev,Manoharan
, p. 1011 - 1014 (2001)
The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of intemucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.
