32766-67-9Relevant academic research and scientific papers
Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters
Hill, Craig M.,Wu, Feiyue,Cheng, Tu-Chen,Defrank, Joseph J.,Raushel, Frank M.
, p. 1285 - 1288 (2000)
The enzyme OPAA hydrolyzes p-nitrophenyl phosphotriesters bearing substituents at the phosphorus center ranging in size from methyl to phenyl. The enzyme exhibits stereoselectivity toward the hydrolysis of chiral substrates with a preference for the S(P)
Synthesis and Phosphorylating Properties of 2-Chloro-2,3-dihydro-3-(methylsulfonyl)-1,3,2-benzoxazaphosphole 2-Oxide. Derivatives with Chloro Substituents on the Benzene Ring
Huensch, Sabine,Richter, Wolfgang,Ugi, Ivar,Chattopadhyaya, Jyoti
, p. 269 - 276 (2007/10/02)
The synthesis and the use of the five-membered cyclic phosphorylating agents 1a-c are described.Their difunctional phosphorylating properties towards alkanols and hydroxylated amino acids and the cleavage reaction of the formed phosphoric acid triesters to diesters with oximate or platinum/hydrogen are investigated and compared to the "parent" compound 2-chloro-2,3-dihydro-3-(methylsulfonyl)-1,3,2-benzoxazaphosphole 2-oxide.Dichlorobenzoxazaphosphole 1b is the most reactive of these reagents with respect to phosphorylation with ring opening and oximate cleavage of the phosphoric acid triesters, followed by o-chlorobenzoxazaphosphole 1a, the unsubstituted phosphole I, and p-chlorobenzoxazaphosphole 1c. - Key Words: Phosphorylating agents, cyclic five-membered / 1,3,2-Benzoxazaphospholes
