32778-08-8

Basic information

• Product Name: 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether
• Synonyms: 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether;Isoflurane Related CoMpound A;1-Chloroisofluorane
• CAS NO: 32778-08-8
• Molecular Formula: C3HCl2F5O
• Molecular Weight: 219
• Mol File: 32778-08-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 81.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.622±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether(32778-08-8)
• EPA Substance Registry System: 1-Chloro-2,2,2-trifluoroethyl chlorodifluoroMethyl ether(32778-08-8)

Safety Data

• RIDADR: UN 3334
• Hazardous Substances Data: 32778-08-8(Hazardous Substances Data)

Usage

Uses

1-Chloroisofluorane is an isomer of Isofluorane (I816800), an inhalational general anaesthetic.

Upstream product

• 26644-89-3 1-Chlor-2,2,2-trifluorethyl-trichlormethylether 
• 1885-48-9 1,1,1-trifluoro-2-difluoromethoxypropane 

Relevant articles and documents

Chiral interactions of the fluoroether anesthetics desflurane, isoflurane, enflurane, and analogues with modified cyclodextrins studied by capillary gas chromatography and nuclear magnetic resonance spectroscopy: A simple method for column-suitability screening

Eighteen chiral analogues of the chiral fluoroether anesthetics desflurane, isoflurane, and enflurane are synthesized and studied by capillary GC on four cyclodextrin-derived stationary phases. Trends in separability and elution order of enantiomers are related to structure and absolute configuration. In particular, a very large separation factor is found for the commercial anesthetic desflurane using Lipodex E stationary phase, suggesting that a preparative enantiomer separation is possible. One of the stationary phases, Cyclodex G-TA, is found to be a chiral shift reagent for several of the fluoroethers. A rough correspondence is found relating the enantiomeric separation factor of a fluoroether and the chemical shift differences between its 1H and 19F nuclei in the NMR spectrum. Based on this data, it is proposed that a simple NMR experiment can screen chiral stationary phases prior to a desired gas chromatographic enantiomer separation of a given chiral compound. Copyright

General anesthetics. 1. Halogenated methyl ethyl ethers as anesthetic agents.

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