32787-79-4Relevant academic research and scientific papers
Antiglycation activity of triazole schiff’s bases against fructose-mediated glycation: In vitro and in silico study
Choudhary, Muhammad I.,Imad, Rehan,Khan, Khalid M.,Naqeeb, Uzma,Shaikh, Muniza,Siddiqui, Salman,Subzwari, Fakiha,Zafar, Humaira
, p. 575 - 591 (2020/06/21)
Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objec
An Efficient Synthesis and Antibacterial Activity of Some Novel 2-Azetidinone Derivatives of 4H-1,2,4-Triazoles Under Mild Conditions
Khan, Takallum,Yadav, Ritu,Gound, Surendra Singh
supporting information, p. 1042 - 1047 (2018/02/23)
We have synthesized the novel 2-azetidinone derivatives by using Schiff bases of 1,2,4-triazoles via a single step protocol. We used DABCO as a good homogenous, ecofriendly, highly reactive, easy to handle, and nontoxic catalyst. In?DABCO catalyzed synthesis of active 2-oxo-azetidine, a highly electrophilic ketene intermediate can react with weakly nucleophilic (N═CH) linkage, which is used as the precursor for the cycloaddition reaction to deliver the desired products in excellent yields with protic solvents. In addition, the DABCO as an economically viable and readily available catalyst is soluble in almost all solvents and their salts easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion in green solvents and a straightforward procedure.
Halogen-bonding contacts determining the crystal structure and fluorescence properties of organic salts
Wang, Jing-Wen,Chen, Chen,Li, Yao-Ja,Luo, Yang-Hui,Sun, Bai-Wang
supporting information, p. 9444 - 9452 (2017/08/29)
By using the ligands 4-(4-bromobenzylideneamino)-4H-1,2,4-triazole (L1) and 4-(4-iodobenzylideneamino)-4H-1,2,4-triazole (L2), four different organic salts HL1+·Cl- (1), L1·HL1s
Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1
Khan, Khalid Mohammed,Siddiqui, Salman,Saleem, Muhammad,Taha, Muhammad,Saad, Syed Muhammad,Perveen, Shahnaz,Choudhary, M. Iqbal
supporting information, p. 6509 - 6514 (2015/02/19)
A series of Schiff base triazoles 1-25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 ± 2.89 μM), 13 (IC50
Dominant role of C-Bra??N halogen bond in molecular self-organization. Crystallographic and quantum-chemical study of schiff-base-containing triazoles
Berski, S??awomir,Ciunik, Zbigniew,Drabent, Krzysztof,Latajka, Zdzis??aw,Panek, Jaros??aw
, p. 12327 - 12332 (2007/10/03)
Three Schiff-base-containing triazole derivatives have been synthesized and investigated by X-ray crystallography. Structural motifs (zigzag or linear chains) formed in the solid state are stabilized by C-Bra??N halogen bond interactions, while hydrogen bonds do not seem to play a significant role in the molecular self-organization of studied compounds. Quantum-chemical studies confirm that these interactions are sufficient to account for both the arrangement of structural motifs and very short Bra??N distances observed experimentally. It is also shown that Bra??N interactions can lead to generally shorter donor-acceptor distances than Cla??N contacts.
REACTION OF SCHIFF BASES OBTAINED FROM 4-AMINOANTIPYRINE AND 4-AMINO-1,2,4-TRIAZOLE WITH KETONES
Letunov, V. I.
, p. 145 - 149 (2007/10/02)
With acetophenone and p-nitroacetophenone in alcohol and benzene media in the presence of acid N-arylidene-4-aminoantipyrines form α,β-unsaturated ketones, and with antipyrine the form aryldiantipyrylmethanes.With the same ketones N-arylidene-4-amino-1,2,4-triazoles form the products from addition at the azomethine bond.In both cases reaction with benzylideneacetone was not detected.
