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Product FOB Price Min.Order Supply Ability Supplier
Oxalacetic acid Manufacturer/High quality/Best price/In stock
Cas No: 328-42-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Factory Supply Oxalacetic acid
Cas No: 328-42-7
No Data 1 1 Ality Chemical Corporation Contact Supplier
Factory price Cosmetic OXOSUCCINIC ACID 328-42-7 Manufacturer
Cas No: 328-42-7
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Oxalacetic acid
Cas No: 328-42-7
USD $ 1.2-5.0 / Kiloliter 5 Kiloliter 3000 Metric Ton/Month Chemwill Asia Co., Ltd. Contact Supplier
Oxobutanedioic acid
Cas No: 328-42-7
USD $ 3.0-3.0 / Gram 1 Gram 1 Metric Ton/Week GIHI CHEMICALS CO.,LIMITED Contact Supplier
TIANFUCHEM--328-42-7--High purity Oxobutanedioic acid in stock
Cas No: 328-42-7
USD $ 2000.0-2000.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
GMP factory supplyCAS 328-42-7 with high-quality service
Cas No: 328-42-7
USD $ 146.0-176.0 / Gram 10 Gram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Oxobutanedioic acid cas328-42-7
Cas No: 328-42-7
USD $ 7.0-9.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Hebei Sankai Chemical Technology Co., Ltd Contact Supplier
Oxobutanedioic acid
Cas No: 328-42-7
USD $ 1.0-10.0 / Kilogram 1 Kilogram 200 Metric Ton/Day Hebei Nengqian Chemical Import and Export Co., LTD Contact Supplier
Butanedioic acid,2-oxo- 328-42-7
Cas No: 328-42-7
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier

328-42-7 Usage


Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; ) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.

Chemical Properties

off-white crystals


Different sources of media describe the Uses of 328-42-7 differently. You can refer to the following data:
1. A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase.
2. Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.
3. Oxaloacetic acid is a substrate for malate dehydrogenase and oxaloacetate decarboxylase. It is an inhibitor of succinic dehydrogenase. It is an intermediate in the citric acid cycle and glucogenesis.


ChEBI: An oxodicarboxylic acid that is succinic acid bearing a single oxo group.

General Description

Oxaloacetic acid is a dicarboxylic acid. It is an intermediate in the citric acid cycle. It is highly soluble in water and is present ubiquitously. It is produced in the mitochondria by the action of pyruvate carboxylase on pyruvate. Breakdown products of oxaloacetate includes malate, pyruvate and aspartic acid.

Flammability and Explosibility


Biological Activity

Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.

Biochem/physiol Actions

Oxaloacetic acid being an intermediate in the tri carboxylic cycle is central to metabolism. It is part of gluconeogenesis pathway. Mutation in pyruvate carboxylase leads to decreased production of oxaloacetate. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.

Purification Methods

Crystallise it from boiling EtOAc, or from hot Me2CO/hot *C6H6. [Beilstein 3 IV 1808.]

Check Digit Verification of cas no

The CAS Registry Mumber 328-42-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,2 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 328-42:
57 % 10 = 7
So 328-42-7 is a valid CAS Registry Number.

328-42-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A12739)  Oxalacetic acid, 97%    328-42-7 5g 474.0CNY Detail
Alfa Aesar (A12739)  Oxalacetic acid, 97%    328-42-7 25g 1959.0CNY Detail
Alfa Aesar (A12739)  Oxalacetic acid, 97%    328-42-7 100g 6725.0CNY Detail
Alfa Aesar (15789)  Oxalacetic acid, 98+%    328-42-7 2g 254.0CNY Detail
Alfa Aesar (15789)  Oxalacetic acid, 98+%    328-42-7 10g 1246.0CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name oxaloacetic acid

1.2 Other means of identification

Product number -
Other names 2-Oxosuccinic acid,Ketosuccinic acid,Oxalacetic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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