3280-48-6

Basic information

• Product Name: chloroanhydride of the p-chlorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acV
• Synonyms: chloroanhydride of the p-chlorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acV
• CAS NO: 3280-48-6
• Molecular Weight: 350.997
• Mol File: 3280-48-6.mol

Chemical Properties

• CAS DataBase Reference: chloroanhydride of the p-chlorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acV(CAS DataBase Reference)
• NIST Chemistry Reference: chloroanhydride of the p-chlorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acV(3280-48-6)
• EPA Substance Registry System: chloroanhydride of the p-chlorophenyl ester of N,N-bis(2-chloroethyl)amidophosphoric acV(3280-48-6)

Safety Data

• Hazardous Substances Data: 3280-48-6(Hazardous Substances Data)

Upstream product

• 127-88-8 N,N-di(2-chloroethyl)amidophosphoric acid dichloride 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 1254975-87-5 C₂₅H₂₁Cl₃NO₆P 
• 81175-85-1 C₁₆H₂₆Cl₃N₂O₈PS₂ 
• 81175-77-1 C₁₄H₂₂Cl₃N₂O₄P 

Relevant articles and documents

Synthesis, cytotoxicity, topoisomerase I inhibition and molecular docking of novel phosphoramide mustard sophoridinic acid analogues

A series of novel phosphoramide mustard sophoridinic acid analogues, consisting of nitrogen mustard group and sophoridinic acid scaffold, have been designed, synthesized and evaluated for their topoisomerase inhibitory activity as well as cytotoxicity against six tumor cell lines (SMMC-7721, LoVo, MCF-7, K562, S180 and H22) and a normal cell line (L929). Among the compounds tested, five were found to be potent inhibitors and exhibited potent cytotoxicity against S180 and H22 cell lines with IC50 values of 1–4?μM. Further mechanistic studies showed that this class of compounds acted as novel topoisomerase I (Topo I) catalytic inhibitors by preventing the binding of Topo I to DNA and inhibiting the cleavage of DNA, and molecular docking studies revealed that the binding energy for these compounds was comparable to that for classic Topo I inhibitors CPT and HCPT, indicating that the compounds have an interaction with DNA and Topo I.

Novel sophoridine derivatives bearing phosphoramide mustard moiety exhibit potent antitumor activities in vitro and in vivo

Novel mustard functionalized sophoridine derivatives were synthesized and evaluated for their cytotoxicity against of a panel of various cancer cell lines. They were shown to be more sensitive to S180 and H22 tumor cells with IC50 values ranging from 1.01–3.65 μM, and distinctly were more cytotoxic to cancer cells than normal cell L929. In addition, compounds 7a, 7c, and 7e displayed moderate tumor suppression without apparent organ toxicity in vivo against mice bearing H22 liver tumors. Furthermore, they arrested tumor cells in the G1 phase and induced cellular apoptosis. Their potential binding modes with DNA-Top I complex have also been investigated.

A convenient synthesis of chrysin-7-yl aryl N-bis(2-chloroethyl) phosphoramidate

A series of novel chrysin-7-yl aryl N-bis(2-chloroethyl) phosphoramidates have been synthesised in good yield via phosphorylation reactions and their structures were elucidated by IR, NMR and elemental analysis.

ARYL ESTERS OF N,N-BIS(2-CHLOROETHYL)-N',N'-BIS(METHANESULFONYLOXYETHYL)DIAMIDOPHOSPHORIC ACID

1.It has been found possible to synthesize phsophorylated derivates of esters of methanesulfonic acid containing chloroethyl amino groups. 2.A study has been made of the reaction betrween the chloanhydrides of aryl esters of N,N-bis(2-chloroethyl)amidopho