328047-41-2Relevant academic research and scientific papers
2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors
Sakamuri, Sukumar,Enyedy, Istvan J.,Zaman, Wahiduz A.,Tella, Srihari R.,Kozikowski, Alan P.,Flippen-Anderson, Judith L.,Farkas, Tivadar,Johnson, Kenneth M.,Wang, Shaomeng
, p. 1123 - 1136 (2007/10/03)
There is considerable interest in developing dopamine transporter (DAT) inhibitors as potential therapies for the treatment of cocaine abuse. We report herein our pharmacophore-based discovery and molecular modeling-assisted rational design of 2,3-disubst
Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors
Sakamuri,Enyedy,Kozikowski,Wang
, p. 9949 - 9952 (2007/10/03)
The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.
