328086-31-3Relevant academic research and scientific papers
Formation of benzo[b]fluorenes and the benzo[a]fluorene core of the fluostatins by cyclization of diaryldiynones.
Atienza,Mateo,de Frutos,Echavarren
, p. 153 - 155 (2001)
[figure: see text] Thermal cyclization of 1-[2-(trimethylsilylethynyl)phenyl]-3-arylpropinones was expected to give benzo[b]fluorenones. However, benzo[a]-fluorenones were also formed as a result of a new rearrangement. These tetracycles possess the core structure of the fluostatins and isoprekinamycin.
Synthesis of the benzo[b]fluorene core of the kinamycins by arylalkyne-allene and arylalkyne-alkyne cycloadditions
Gonzalez-Cantalapiedra, Esther,De Frutos, Oscar,Atienza, Carmen,Mateo, Cristina,Echavarren, Antonio M.
, p. 1430 - 1443 (2007/10/03)
Arylalkyne-allene and arylalkyne-alkyne cycloadditions yields benzo[a]fluorenones, which are related to the tetracyclic core of the kinamycins. In the arylalkyne-alkyne cycloadditions, we found a rearrangement that produces benzo-[a]fluorenones, in addition to the expected benzo[b]fluorenones. This rearrangement could be suppressed in the presence of phenol, which allowed the synthesis of 4,9-dimeth-oxy-2-methyl-11H-benzo[b] fluoren-11-one in excellent yield. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
