328087-59-8

Upstream product

• 98-01-1 furfural 
• 445-27-2 2'-Fluoroacetophenone 
• 109-77-3 malononitrile 
• 24090-00-4 (Z)-1-(2-Fluoro-phenyl)-3-furan-2-yl-propenone 

Downstream Products

• 328087-63-4 4-amino-7-(2-fluoro-phenyl)-5-furan-2-yl-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 329190-12-7 7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione 
• 400031-82-5 7-(2-fluoro-phenyl)-5-furan-2-yl-3-(2-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one 
• 400031-61-0 2-amino-6-(2-fluoro-phenyl)-4-furan-2-yl-nicotinamide 

Relevant academic research and scientific papers

Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents

Two series of compounds with the general formula of 4,6-diaryl-2-oxo-1,2 dihydropyridine-3-carbonitriles and their isosteric imino derivatives were synthesized through a one pot reaction of acetophenone, aldehyde and ammonium acetate with ethyl cyanoacetate or malononitrile, respectively. The synthesized compounds were evaluated for tumor cell growth inhibitory using the human HT-29 colon and MDA-MB-231 breast tumor cell lines. Compound 4-(2-Ethoxyphenyl)-2- imino-6-(4-fluorophenyl)-1,2-dihydropyridine-3 carbonitrile (6) showed IC 50 value of 0.70 μM versus HT-29. Meanwhile, compound 4-(2-Hydroxyphenyl)-2-imino-6-(4-fluorophenyl)-1,2-dihydropyridine-3- carbonitrile (4) showed IC50 value of 4.6 μM versus MDA-MB-231. Docking compound 10 to possible molecular targets, survivin and PIM1 kinase showed appreciable interactions with both, which suggest possible targets for the antitumor activity of this novel class of anticancer compounds.

Synthesis of some new pyrido[2,3-d]pyrimidines and their ribofuranosides as possible antimicrobial agents

The ribofuranosides, namely, 4-amino-5,7-disubstituted-1-[2′,3′,5′- tri-O-benzoyl-α-D-ribofuranosyl]pyrido-[2,3-d] pyrimidine-2(1H)-thiones, have been synthesized by the condensation of trimethylsilyl derivatives of 5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones with β-D-ribofuranose-1-acetate-2,3,5-tribenzoate in the presence of SnCl4. The heterocyclic bases, namely, 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones, were synthesized by the treatment of 2-amino-3-cyano-4,6-disubstituted pyridines with thiourea. The structures of all the synthesized ribofuranosides and their precursors have been established by elemental analysis, IR, and 1H NMR spectral data. The 13C NMR data of ribofuranosides has also been presented. All the synthesized heterocyclic bases and their ribofuranosides have been screened for their antibacterial and antifungal activities.

Synthesis of some 2-thioxopyrido[2,3-d]pyrimidine ribofuranosides and their antimicrobial activity

2-Thioxo-3,5,7-trisubstituted-1-[2′,3′.5′-tri-O-benzoyl-β -D-ribofuranosyl]pyrido[2,3-d]pyri midin-4(IH)-ones have been prepared by the condensation of trimethylsilyl derivative of 2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with β-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by IR. 1H NMR and elemental analysis. These derivatives have been screened for their antimicrobial activity.

Synthesis of some novel 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones and their nucleosides as potential therapeutic agents

Some newer 4-imino-3,5,7-trisubstituted pyrido[2,3-d]pyrimidine-2(1H)-thiones were synthesized by the condensation of 2-amino-3-cyano-4,6-disubstituted pyridines with phenylisothiocyanate. The nucleosides viz., 4-imino-3,5,7-trisubstituted-1-(2,3,5-tri-O-