328261-48-9

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 141-97-9 ethyl acetoacetate 
• 109-77-3 malononitrile 
• 7803-57-8 hydrazine hydrate 

Relevant academic research and scientific papers

L-Proline as an efficicent catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in water

An efficient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4- dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using l-proline (10 mol %) in water under mild reaction condition in excellent yields is established. A comparative study of l-proline with γ-alumina, basic alumina, and KF-alumina was also carried out. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.

Synthesis of pyranopyrazoles using nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 as a new Schiff base complex and catalyst

By the condensation reaction of benzaldehyde with ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of FeCl2, a pyranopyrazole derivative was prepared which was then reacted with salicylaldehyde to afford nano-Fe-[phenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Fe-PSMP]Cl2). The prepared nano-Schiff base complex was fully characterized using Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential thermogravimetry, scanning electron microscopy and UV–visible spectroscopy, and was used as an efficient and catalyst for the preparation of pyranopyrazoles.

Synthesis of pyrano[2,3-c]pyrazole derivatives using Fe3O4@SiO2@piperidinium benzene-1,3-disulfonate (Fe3O4@SiO2 nanoparticle-supported IL) as a novel, green and heterogeneous catalyst

A simple, green and efficient protocol for the one-pot four-component synthesis of pyrano[2,3-c]pyrazole derivatives produced from reaction between aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of nano magnetic piperidinium benzene-1,3-disulfonate was synthesized in water at 60 °C. The Fe3O4@SiO2 nanoparticle-supported IL was designed and synthesized. The present process offers advantages such as clean reaction, short reaction time, good to excellent yield, easy purification and easy recoverable catalyst.

Synthesis of pyranopyrazole derivatives by in situ generation of trityl carbocation under mild and neutral media

Abstract: In this work, synthesis of pyranopyrazole derivatives by the one-pot tandem four component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate in the presence of Ph3CCl at 60?°C under

A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-c]pyrazole-5-carbonitriles in deep eutectic solvent

A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-c]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes (1a-o) malanonitrile (2), ethyl acetoacetate (3), and hydrazine hydrate (4) in freshly pr

Magnetic nanoparticle supported hyperbranched polyglycerol catalysts for synthesis of 4H-benzo[b]pyran

A magnetic nanoparticle supported hyperbranched polyglycerol catalyst was prepared readily from inexpensive starting materials in aqueous medium that catalyzed the synthesis of 4H-benzo[b]pyran under solvent-free conditions at room temperature. X-ray diff

Highly efficient solvent-free synthesis of pyranopyrazoles by a Bronsted-acidic ionic liquid as a green and reusable catalyst

A simple, green and efficient protocol for synthesis of dihydropyrano[2,3-c]pyrazole derivatives is developed by a four component reaction of various benzaldehydes, ethyl acetoacetate, hydrazine hydrate and malononitrile in the presence of 3-methyl-1-(4-s

Rapid one-pot, four component synthesis of pyranopyrazoles using heteropolyacid under solvent-free condition

A series of pyranopyrazoles, was efficiently synthesized via one-pot, four component reaction of ethyl acetoacetate, hydrazine hydrate, aldehydes and malononitrile in the presence of catalytic amount silicotungstic acid under solvent free condition. NOE e

γ-Alumina as a recyclable catalyst for the four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles in aqueous medium

γ-Alumina as an expedient and recyclable catalyst for the synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles in water via a four-component reaction is established. Comparative study of the efficacy of γ-alumina, basic alumina and KF-alumina is also discussed. The method presented is mild, environment friendly, inexpensive and functionality tolerable to give the products in good to excellent yields.

Synthesis of substituted pyranopyrazoles under neat conditions via a multicomponent reaction

A simple and efficient synthesis of pyranopyrazoles in good yields via a four-component reaction between an aromatic aldehyde, hydrazine hydrate, ethyl acetoacetate and malononitrile under neat conditions is described. Georg Thieme Verlag Stuttgart.