328261-61-6

Basic information

• Product Name: 2-(benzoylamino)-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
• Synonyms: 2-(benzoylamino)-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
• CAS NO: 328261-61-6
• Molecular Formula: C24H24N2O3S
• Molecular Weight: 420.52396
• Mol File: 328261-61-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(benzoylamino)-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzoylamino)-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide(328261-61-6)
• EPA Substance Registry System: 2-(benzoylamino)-N-(4-methoxyphenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide(328261-61-6)

Safety Data

• Hazardous Substances Data: 328261-61-6(Hazardous Substances Data)

Upstream product

• 885115-88-8 tert-butyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate 
• 333774-32-6 2-(benzoylamino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid 
• 1588502-41-3 C₂₁H₂₅NO₃S 
• 104-94-9 4-methoxy-aniline 
• 107113-11-1 2-phenyl-6,7,8,9-tetrahydro-4H,5H-cyclohepta[4,5]thieno[2,3-d][1,3]oxazin-4-one 
• 502-42-1 cycloheptanone 

Relevant articles and documents

Synthesis and biological evaluation of 2-acetamidothiophene-3-carboxamide derivatives against Leishmania donovani

A high-throughput (HTS) and high-content screening (HCS) campaign of a commercial library identified 2-acetamidothophen-3-carboxamide as a novel scaffold for developing new anti-leishmanial agents. A series of chemical modifications were performed to study the structure-activity relationship (SAR) and in vitro anti-leishmanial activities were evaluated using biological assays of not only extracellular promastigotes but also intracellular amastigotes. Compound 6a showed promising anti-amastigote activity (EC50 = 6.41 μM) against L. donovani without any cytotoxicity (CC50 > 50 μM) towards human macrophages.