328273-28-5

Basic information

• Product Name: methyl 7,24-bis-O-(tert-butyldimethylsilyl)okadaate
• Synonyms: methyl 7,24-bis-O-(tert-butyldimethylsilyl)okadaate
• CAS NO: 328273-28-5
• Molecular Weight: 1047.57
• Mol File: 328273-28-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 7,24-bis-O-(tert-butyldimethylsilyl)okadaate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 7,24-bis-O-(tert-butyldimethylsilyl)okadaate(328273-28-5)
• EPA Substance Registry System: methyl 7,24-bis-O-(tert-butyldimethylsilyl)okadaate(328273-28-5)

Safety Data

• Hazardous Substances Data: 328273-28-5(Hazardous Substances Data)

Upstream product

• 78111-17-8 okadaic acid 

Relevant articles and documents

Selective elimination of human pluripotent stem cells by a marine natural product derivative

One of the current obstacles to stem cell therapy is the tumorigenic potential of residual undifferentiated stem cells. The present study reports rediscovery of a synthetic derivative of okadaic acid, a marine polyether toxin, as a reagent that selectively induces the death of human pluripotent stem cells. Cell-based screening of 333 cytotoxic compounds identified methyl 27-deoxy-27-oxookadaate (molecule 1) as a substrate of two ATP-binding cassette (ABC) transporters, ABCB1 (MDR1) and ABCG2 (BCRP), whose expression is repressed in human embryonic stem cells and induced pluripotent stem cells. The results demonstrate that selective elimination of human pluripotent stem cells can be achieved by designing cytotoxic small molecules with appropriate ABC-transporter selectivity.