328378-38-7Relevant academic research and scientific papers
Fluoro, alkylsulfanyl, and alkylsulfonyl leaving groups in suzuki cross-coupling reactions of purine 2′-deoxynucleosides and nucleosides
Liu, Jiangqiong,Robins, Morris J.
, p. 1149 - 1151 (2007/10/03)
(Chemical Equation Presented) Protected 2′-deoxynucleoside and nucleoside derivatives of 6-fluoropurine, 6-(3-methylbutyl)sulfanylpurine, and 6-(3-methylbutyl)ylsulfonylpurine undergo nickel- or palladium-mediated C-C cross-coupling with arylboronic acids
Azoles as suzuki cross-coupling leaving groups: Syntheses of 6-arylpurine 2′-deoxynucleosides and nucleosides from 6-(lmidazol-1-yl)- and 6-(1,2,4-triazol-4-yl)purine derivatives
Liu, Jiangqiong,Robins, Morris J.
, p. 3421 - 3423 (2007/10/03)
(Chemical Equation Presented) 6-(lmidazol-1-yl)-, 6-(benzimidazol-1-yl)-, and 6-(1,2,4-triazol-4-yl)purine nucleosides undergo a nickel-mediated C-C cross-coupling of azole-substituted purine derivatives with arylboronic acids to give good yields of 6-ary
Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines
Hocek, Michal,Holy, Antonin,Votruba, Ivan,Dvorakova, Hana
, p. 1683 - 1697 (2007/10/03)
9-(2-Deoxy-β-D-erythro-pentofuranosyl)-6-(4-substituted phenyl)purines, 9-(5-deoxy-β-D-ribofuranosyl)-6-(4-substituted phenyl)purines and 9-(2,3-dihydroxypropyl)-6-(4-substituted phenyl)purines were prepared by the Suzuki-Miyaura cross-coupling reactions of the corresponding protected 9-substituted 6-chloropurines with substituted phenylboronic acids followed by MeONa mediated deprotection. In contrast to the highly active 6-phenylpurine ribonucleosides, the title compounds did not show any considerable cytostatic activity.
