328547-41-7Relevant academic research and scientific papers
Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease
Wang, Chenbo,Widom, Julia,Petronijevic, Filip,Burnett, James C.,Nuss, Jonathan E.,Bavari, Sina,Gussio, Rick,Wipf, Peter
experimental part, p. 487 - 520 (2009/12/24)
Based on the lead therapeutic agent NSC 240898, a new series of heterocyclic inhibitors of the BoNT serotype A metalloprotease has been generated. Highlights of the synthetic sequences include Sonogashira couplings of polysubstituted building blocks and gold-catalyzed indole formations. Preliminary structure-activity relationship studies afford detailed insights into the steric and electrostatic properties of the pharmacophore of this molecular scaffold.
